Metabolic influence on the differentiation of suppressive myeloid cells in cancer

被引：26

作者：

Porta, Chiara ^{[1
]}

Marino, Arianna ^{[1
]}

Consonni, Francesca Maria ^{[2
]}

Bleve, Augusto ^{[1
]}

Mola, Silvia ^{[1
]}

Storto, Mariangela ^{[1
]}

Riboldi, Elena ^{[1
]}

Sica, Antonio ^{[1
,2
]}

机构：

[1] Univ Piemonte Orientale Amedeo Avogadro, Dept Pharmaceut Sci, Novara, Italy

[2] Humanitas Clin & Res Ctr, Rozzano, Italy

来源：

CARCINOGENESIS | 2018年 / 39卷 / 09期

关键词：

TUMOR-ASSOCIATED MACROPHAGES; ARYL-HYDROCARBON RECEPTOR; FATTY-ACID OXIDATION; ANTITUMOR IMMUNITY; T-CELLS; INSULIN-RESISTANCE; OBESITY ALTERS; INFLAMMATION; ACTIVATION; PROMOTE;

D O I：

10.1093/carcin/bgy088

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

New evidences indicate that the metabolic instruction of immunity (immune metabolism) results from the integration of cell metabolism and whole-body metabolism, which are both influenced by nutrition, microbiome metabolites and disease-driven metabolism (e.g. cancer metabolism). Cancer metabolism influences the immunological homeostasis and promotes immune alterations that support disease progression, hence influencing the clinical outcome. Cancer cells display increased glucose uptake and fermentation of glucose to lactate, even in the presence of completely functioning mitochondria. A major side effect of this event is immunosuppression, characterized by limited immunogenicity of cancer cells and restriction of the therapeutic efficacy of anticancer immunotherapy. Here, we discuss how the metabolism of myeloid cells associated with cancer contributes to the differentiation of their suppressive phenotype and therefore to cancer immune evasion.

引用

页码：1095 / 1104

页数：10

共 120 条

[71] Entinostat Neutralizes Myeloid-Derived Suppressor Cells and Enhances the Antitumor Effect of PD-1 Inhibition in Murine Models of Lung and Renal Cell Carcinoma [J].

Orillion, Ashley ;

Hashimoto, Ayumi ;

Damayanti, Nur ;

Shen, Li ;

Adelaiye-Ogala, Remi ;

Arisa, Sreevani ;

Chintala, Sreenivasulu ;

Ordentlich, Peter ;

Kao, Chingai ;

Elzey, Bennett ;

Gabrilovich, Dmitry ;

Pili, Roberto .

CLINICAL CANCER RESEARCH, 2017, 23 (17) :5187-5201

[72] M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARβ/δ Activation in Tumor Myeloid Cells, Leading to Tumor Progression [J].

Park, Jonghanne ;

Lee, Sang Eun ;

Hur, Jin ;

Hong, Eun Byeol ;

Choi, Jae-Il ;

Yang, Ji-Min ;

Kim, Ju-Young ;

Kim, Young-Chan ;

Cho, Hyun-Jai ;

Peters, Jeffrey M. ;

Ryoo, Seung-Bum ;

Kim, Young Tae ;

Kim, Hyo-Soo .

CELL REPORTS, 2015, 10 (09) :1614-1625

[73] Dietary Consumption of Black Raspberries or Their Anthocyanin Constituents Alters Innate Immune Cell Trafficking in Esophageal Cancer [J].

Peiffer, Daniel S. ;

Wang, Li-Shu ;

Zimmerman, Noah P. ;

Ransom, Benjamin W. S. ;

Carmella, Steven G. ;

Kuo, Chieh-Ti ;

Chen, Jo-Hsin ;

Oshima, Kiyoko ;

Huang, Yi-Wen ;

Hecht, Stephen S. ;

Stoner, Gary D. .

CANCER IMMUNOLOGY RESEARCH, 2016, 4 (01) :72-82

[74] Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma [J].

Penny, Hweixian Leong ;

Sieow, Je Lin ;

Adriani, Giulia ;

Yeap, Wei Hseun ;

Ee, Peter See Chi ;

San Luis, Boris ;

Lee, Bernett ;

Lee, Terence ;

Mak, Shi Ya ;

Ho, Ying Swan ;

Lam, Kong Peng ;

Ong, Choon Kiat ;

Huang, Ruby Y. J. ;

Ginhoux, Florent ;

Rotzschke, Olaf ;

Kamm, Roger D. ;

Wong, Siew Cheng .

ONCOIMMUNOLOGY, 2016, 5 (08)

[75] Tumor-associated myeloid cells: new understandings on their metabolic regulation and their influence in cancer immunotherapy [J].

Porta, Chiara ;

Sica, Antonio ;

Riboldi, Elena .

FEBS JOURNAL, 2018, 285 (04) :717-733

[76] Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF [J].

Quail, Daniela F. ;

Olson, Oakley C. ;

Bhardwaj, Priya ;

Walsh, Logan A. ;

Akkari, Leila ;

Quick, Marsha L. ;

Chen, I-Chun ;

Wendel, Nils ;

Ben-Chetrit, Nir ;

Walker, Jeanne ;

Holt, Peter R. ;

Dannenberg, Andrew J. ;

Joyce, Johanna A. .

NATURE CELL BIOLOGY, 2017, 19 (08) :974-+

[77] The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils [J].

Raccosta, Laura ;

Fontana, Raffaella ;

Maggioni, Daniela ;

Lanterna, Claudia ;

Villablanca, Eduardo J. ;

Paniccia, Aida ;

Musumeci, Andrea ;

Chiricozzi, Elena ;

Trincavelli, Maria Letizia ;

Daniele, Simona ;

Martini, Claudia ;

Gustafsson, Jan-Ake ;

Doglioni, Claudio ;

Feo, Safiye Gonzalvo ;

Leiva, Andrea ;

Ciampa, Maria Grazia ;

Mauri, Laura ;

Sensi, Cristina ;

Prinetti, Alessandro ;

Eberini, Ivano ;

Mora, J. Rodrigo ;

Bordignon, Claudio ;

Steffensen, Knut R. ;

Sonnino, Sandro ;

Sozzani, Silvano ;

Traversari, Catia ;

Russo, Vincenzo .

JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (09) :1711-1728

[78] Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes That Infiltrate Atherosclerotic Lesions [J].

Robbins, Clinton S. ;

Chudnovskiy, Aleksey ;

Rauch, Philipp J. ;

Figueiredo, Jose-Luiz ;

Iwamoto, Yoshiko ;

Gorbatov, Rostic ;

Etzrodt, Martin ;

Weber, Georg F. ;

Ueno, Takuya ;

van Rooijen, Nico ;

Mulligan-Kehoe, Mary Jo ;

Libby, Peter ;

Nahrendorf, Matthias ;

Pittet, Mikael J. ;

Weissleder, Ralph ;

Swirski, Filip K. .

CIRCULATION, 2012, 125 (02) :364-U415

[79] Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation [J].

Rodriguez-Prados, Juan-Carlos ;

Traves, Paqui G. ;

Cuenca, Jimena ;

Rico, Daniel ;

Aragones, Julian ;

Martin-Sanz, Paloma ;

Cascante, Marta ;

Bosca, Lisardo .

JOURNAL OF IMMUNOLOGY, 2010, 185 (01) :605-614

[80] Retinoid X receptors in macrophage biology [J].

Roszer, Tamas ;

Menendez-Gutierrez, Maria P. ;

Cedenilla, Marta ;

Ricote, Mercedes .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2013, 24 (09) :460-468

← 3 4 5 6 7 8 9 10 11 12 →