Synthesis and characterization of new water stable antimony(III) complex with pyrimidine-2-thione and in vitro biological study

A novel water stable, antimony(III) complex with the heterocyclic thioamide, 2-mercapto-pyrimidine (pmtH), of formula [Sb(pmt)(3)]center dot 0.5(CH3OH), has been synthesized and characterized by elemental analysis, H-1, C-13 NMR and FT-IR spectroscopic techniques. Crystal structure of the molecule has been determined by X-ray diffraction at ambient conditions. The compound [C12H9N6S3Sb center dot 0.5(CH3OH)] is monoclinic, space group P2(1)/c, a=7.0646(7), b=16.3767(14), e=14.7265(13) angstrom, beta=92.016(7)degrees, Z=4. In complex, three sulfur and three nitrogen atoms from thione ligands form a distorted pendagonal pyramidal geometry around antimony(III). The toxicity of the compound against tumor pleiomorphic cells, which has been isolated from a leiomyosarcoma tumor in the Wistar rat (chemical carcinogenesis using BaP) was studied in vitro. The results show that the compound did not destroy or prevent multiplication in vitro in leiomyosarcoma cells in low doses. The influence of the compound in the platelet aggregation, which correlates with the above tumor cells enhanced metastatic potential, has also been studied. The anti-metastatic capability study shows that the compound inhibited cancer cell induced aggregation up to the value of 10% in all mM concentrations tested. (c) 2004 Elsevier B.V. All rights reserved.