The Role of Notch Signaling Pathway in Non-Alcoholic Fatty Liver Disease

被引：27

作者：

Xu, Hao ^{[1
]}

Wang, Lin ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xi Jing Hosp, Dept Hepatobiliary Surg, Xian, Peoples R China

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2021年 / 8卷

关键词：

Notch signaling pathway; non-alcoholic fatty liver disease (NAFLD); steatohepatitis; lipid metabolism; insulin resistance (IR); fibrogenesis; autophagy; INSULIN-RESISTANCE; ADIPOSE-TISSUE; OXIDATIVE STRESS; HEPATOCELLULAR-CARCINOMA; HEPATIC STEATOSIS; RECENT INSIGHTS; LIPID DROPLETS; FIBROSIS STAGE; VITAMIN-E; KAPPA-B;

D O I：

10.3389/fmolb.2021.792667

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and progressive NAFLD can develop into non-alcoholic steatohepatitis (NASH), liver cirrhosis, or hepatocellular carcinoma (HCC). NAFLD is a kind of metabolic disordered disease, which is commonly associated with lipid metabolism, insulin resistance, oxidative stress, inflammation, and fibrogenesis, as well as autophagy. Growing studies have shown Notch signaling pathway plays a pivotal role in the regulation of NAFLD progression. Here, we review the profile of the Notch signaling pathway, new evidence of Notch signaling involvement in NAFLD, and describe the potential of Notch as a biomarker and therapeutic target for NAFLD treatment.

引用

页数：12

共 134 条

[71] Exogenous administration of DLK1 ameliorates hepatic steatosis and regulates gluconeogenesis via activation of AMPK [J].

Lee, Y-h ;

Yun, M. R. ;

Kim, H. M. ;

Jeon, B. H. ;

Park, B-C ;

Lee, B-W ;

Kang, E. S. ;

Lee, H. C. ;

Park, Y. W. ;

Cha, B-S .

INTERNATIONAL JOURNAL OF OBESITY, 2016, 40 (02) :356-365

[72] Target genes associated with lipid and glucose metabolism in non-alcoholic fatty liver disease [J].

Li, Ting ;

Yan, Hua ;

Geng, Yan ;

Shi, Haitao ;

Li, Hong ;

Wang, Shenhao ;

Wang, Yatao ;

Xu, Jingyuan ;

Zhao, Gang ;

Lu, Xiaolan .

LIPIDS IN HEALTH AND DISEASE, 2019, 18 (01)

[73] Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice [J].

Lin, Chih-Wen ;

Zhang, Hao ;

Li, Min ;

Xiong, Xiwen ;

Chen, Xi ;

Chen, Xiaoyun ;

Dong, Xiaocheng C. ;

Yin, Xiao-Ming .

JOURNAL OF HEPATOLOGY, 2013, 58 (05) :993-999

[74] Hepatocellular carcinoma [J].

Llovet, Josep M. ;

Kelley, Robin Kate ;

Villanueva, Augusto ;

Singal, Amit G. ;

Pikarsky, Eli ;

Roayaie, Sasan ;

Lencioni, Riccardo ;

Koike, Kazuhiko ;

Zucman-Rossi, Jessica ;

Finn, Richard S. .

NATURE REVIEWS DISEASE PRIMERS, 2021, 7 (01)

[75] Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease [J].

Lomonaco, Romina ;

Ortiz-Lopez, Carolina ;

Orsak, Beverly ;

Webb, Amy ;

Hardies, Jean ;

Darland, Celia ;

Finch, Joan ;

Gastaldelli, Amalia ;

Harrison, Stephen ;

Tio, Fermin ;

Cusi, Kenneth .

HEPATOLOGY, 2012, 55 (05) :1389-1397

[76] Mechanisms and disease consequences of nonalcoholic fatty liver disease [J].

Loomba, Rohit ;

Friedman, Scott L. ;

Shulman, Gerald, I .

CELL, 2021, 184 (10) :2537-2564

[77] Hydrogen peroxide sensing, signaling and regulation of transcription factors [J].

Marinho, H. Susana ;

Real, Carla ;

Cyrne, Luisa ;

Soares, Helena ;

Antunes, Fernando .

REDOX BIOLOGY, 2014, 2 :535-562

[78] Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo1 in liver [J].

Matsumoto, Michihiro ;

Pocai, Alessandro ;

Rossetti, Luciano ;

DePinho, Ronald A. ;

Accili, Domenico .

CELL METABOLISM, 2007, 6 (03) :208-216

[79] NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway [J].

McDaniell, Ryan ;

Warthen, Daniel M. ;

Sanchez-Lara, Pedro A. ;

Pai, Athma ;

Krantz, Ian D. ;

Piccoli, David A. ;

Spinner, Nancy B. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2006, 79 (01) :169-173

[80] Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology [J].

Mederacke, Ingmar ;

Hsu, Christine C. ;

Troeger, Juliane S. ;

Huebener, Peter ;

Mu, Xueru ;

Dapito, Dianne H. ;

Pradere, Jean-Philippe ;

Schwabe, Robert F. .

NATURE COMMUNICATIONS, 2013, 4

← 3 4 5 6 7 8 9 10 11 12 →