The Evolving Microbiome from Pregnancy to Early Infancy: A Comprehensive Review

被引：88

作者：

Dolores Mesa, Maria ^{[1
,2
]}

Loureiro, Begona ^{[3
]}

Iglesia, Iris ^{[4
,5
]}

Fernandez Gonzalez, Sergi ^{[6
,7
,8
]}

Llurba Olive, Elisa ^{[9
,10
,11
]}

Garcia Algar, Oscar ^{[6
,7
,12
]}

Jose Solana, Maria ^{[13
]}

Cabero Perez, Ma Jesus ^{[14
]}

Sainz, Talia ^{[15
,16
,17
]}

Martinez, Leopoldo ^{[16
,18
]}

Escuder-Vieco, Diana ^{[19
]}

Parra-Llorca, Anna ^{[20
]}

Sanchez-Campillo, Maria ^{[21
]}

Rodriguez Martinez, Gerardo ^{[5
,22
]}

Gomez Roig, Dolores ^{[6
,7
,8
]}

Perez Gruz, Myriam ^{[6
,7
,8
]}

Andreu-Fernandez, Vicente ^{[6
,7
,12
]}

Clotet, Jordi ^{[6
,7
,12
]}

Sailer, Sebastian ^{[6
,7
,12
]}

Iglesias-Platas, Isabel ^{[6
,7
,8
,23
]}

Lopez-Herce, Jesus ^{[13
]}

Aras, Rosa ^{[16
]}

Pallas-Alonso, Carmen ^{[19
]}

Saenz de Pipaon, Miguel ^{[24
]}

Vento, Maximo ^{[20
]}

Gormaz, Maria ^{[20
]}

Larque Daza, Elvira ^{[21
]}

Calvo, Cristina ^{[15
,16
,17
,25
]}

Cabanas, Fernando ^{[26
,27
]}

机构：

[1] Univ Granada, Dept Biochem & Mol Biol 2, Inst Nutr & Food Technol Jose Mataix, Biomed Res Ctr, Parque Tecnol Salud,Ave Conocimiento S-N, Granada 18100, Spain

[2] Complejo Hosp Univ Granada, Inst Invest Biosanitaria, Ibs GRANADA, Granada 18014, Spain

[3] Univ Hosp Cruces, Biocruces Bizkaia Hlth Res Inst, Neonatol Unit, Baracaldo 48903, Spain

[4] Univ Zaragoza, Growth Exercise Nutr & Dev GENUD Res Grp, E-50009 Zaragoza, Spain

[5] IIS Aragon, Zaragoza 50009, Spain

[6] Hosp St Joan de Deu, BCNatal Barcelona Ctr Maternal Fetal & Neonatal M, Barcelona 08028, Spain

[7] Hosp Clin Barcelona, Barcelona 08028, Spain

[8] IR SJD, Barcelona 08028, Spain

[9] St Pau Univ Hosp, High Risk Unit, Dept Obstet & Gynecol, Barcelona 08025, Spain

[10] St Pau Univ Hosp, Biomed Res Inst St Pau IIB St Pau, Women & Perinatal Hlth Res Grp, Barcelona 08041, Spain

[11] Univ Autonoma Barcelona, Sch Med, E-08193 Barcelona, Spain

[12] BCNatal, ICGON, Hosp Clin Maternitat, Neonatol Unit, Gran Via Corts Catalanes 585, Barcelona 08007, Spain

[13] Univ Complutense Madrid, Hosp Gen Univ Gregorio Maranon, Serv Cuidados Intens Pediat, Dept Salud Publ & Materno Infantil, E-28040 Madrid, Spain

[14] Hosp Univ Marques Valdecilla, Santander 39008, Cantabria, Spain

[15] Hosp La Paz, Serv Pediat Enfermedades Infecciosas & Trop, Madrid 28046, Spain

[16] Hosp La Paz, Inst Invest, Madrid 28029, Spain

[17] RITIP, Madrid 28046, Spain

[18] Hosp La Paz, Serv Cirugia Pediat, Madrid 28046, Spain

[19] Univ Complutense, Univ Hosp 12 Octubre, Donated Milk Bank, Hlth Res Inst I 12, E-28040 Madrid, Spain

[20] Univ & Polytech Hosp La Fe, Hlth Res Inst LA Fe, Neonatal Res Grp, Valencia 46026, Spain

[21] Univ Murcia, Fac Biol, Dept Physiol, E-30100 Murcia, Spain

[22] Hosp Clin Univ Lozano Blesa, Fac Med, Dept Pediat, Zaragoza 50009, Spain

[23] Hosp St Joan de Deu, Inst Recerca St Joan de Deu, BCNatal, Neonatol Unit, Barcelona 08028, Spain

[24] La Paz Univ Hosp, Dept Neonatol, Madrid 28046, Spain

[25] European Network Excellence Pediat Clin Res, I-27100 Pavia, Italy

[26] Madrid Univ Hosp, Dept Paediat Neonatol Quironsalud, Madrid 28046, Spain

[27] La Paz Univ Hosp, IDIPAZ, Biomed Res Fdn, Madrid 28046, Spain

来源：

NUTRIENTS | 2020年 / 12卷 / 01期

关键词：

microbiome; pregnancy; fetus; placenta; newborn; infancy; critical illness; sepsis; allergy; HUMAN GUT MICROBIOME; LOW-BIRTH-WEIGHT; INTESTINAL MICROBIOTA; VAGINAL MICROBIOTA; CESAREAN-SECTION; COMMENSAL MICROBIOTA; MATERNAL OBESITY; PRETERM INFANTS; ATOPIC DISEASE; DELIVERY MODE;

D O I：

10.3390/nu12010133

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Pregnancy induces a number of immunological, hormonal, and metabolic changes that are necessary for the mother to adapt her body to this new physiological situation. The microbiome of the mother, the placenta and the fetus influence the fetus growth and undoubtedly plays a major role in the adequate development of the newborn infant. Hence, the microbiome modulates the inflammatory mechanisms related to physiological and pathological processes that are involved in the perinatal progress through different mechanisms. The present review summarizes the actual knowledge related to physiological changes in the microbiota occurring in the mother, the fetus, and the child, both during neonatal period and beyond. In addition, we approach some specific pathological situations during the perinatal periods, as well as the influence of the type of delivery and feeding.

引用

页数：21

共 163 条

[1] The Placenta Harbors a Unique Microbiome
Aagaard, Kjersti
Ma, Jun
Antony, Kathleen M.
Ganu, Radhika
Petrosino, Joseph
Versalovic, James
[J]. SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (237)
[2] A Metagenomic Approach to Characterization of the Vaginal Microbiome Signature in Pregnancy
Aagaard, Kjersti
Riehle, Kevin
Ma, Jun
Segata, Nicola
Mistretta, Toni-Ann
Coarfa, Cristian
Raza, Sabeen
Rosenbaum, Sean
Van den Veyver, Ignatia
Milosavljevic, Aleksandar
Gevers, Dirk
Huttenhower, Curtis
Petrosino, Joseph
Versalovic, James
[J]. PLOS ONE, 2012, 7 (06):
[3] Low gut microbiota diversity in early infancy precedes asthma at school age
Abrahamsson, T. R.
Jakobsson, H. E.
Andersson, A. F.
Bjorksten, B.
Engstrand, L.
Jenmalm, M. C.
[J]. CLINICAL AND EXPERIMENTAL ALLERGY, 2014, 44 (06) : 842 - 850
[4] An insight into gut microbiota and its functionalities
Adak, Atanu
Khan, Mojibur R.
[J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2019, 76 (03) : 473 - 493
[5] [Anonymous], HIGH THROUGHPUT
[6] [Anonymous], 2016, FRONT MICROBIOL, DOI DOI 10.3389/fmicb.2016.01031
[7] [Anonymous], 2014, Perinat. Prenat. Disord.
[8] The preterm placental microbiome varies in association with excess maternal gestational weight gain
Antony, Kathleen M.
Ma, Jun
Mitchell, Kristen B.
Racusin, Diana A.
Versalovic, James
Aagaard, Kjersti
[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2015, 212 (05) : 653.e1 - 653.e16
[9] Meconium Microbiome Analysis Identifies Bacteria Correlated with Premature Birth
Ardissone, Alexandria N.
de la Cruz, Diomel M.
Davis-Richardson, Austin G.
Rechcigl, Kevin T.
Li, Nan
Drew, Jennifer C.
Murgas-Torrazza, Roberto
Sharma, Renu
Hudak, Mark L.
Triplett, Eric W.
Neu, Josef
[J]. PLOS ONE, 2014, 9 (03):
[10] Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months
Azad, Meghan B.
Konya, Theodore
Maughan, Heather
Guttman, David S.
Field, Catherine J.
Chari, Radha S.
Sears, Malcolm R.
Becker, Allan B.
Scott, James A.
Kozyrskyj, Anita L.
[J]. CANADIAN MEDICAL ASSOCIATION JOURNAL, 2013, 185 (05) : 385 - 394

← 1 2 3 4 5 6 7 8 9 10 →