An effective synthetic route to EF5

被引：8

作者：

Baird, IR

Skov, KA

James, BR

Rettig, SJ

Koch, CJ

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

[2] British Columbia Canc Res Ctr, Adv Therapeut, Vancouver, BC V5Z 1L3, Canada

[3] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA

来源：

SYNTHETIC COMMUNICATIONS | 1998年 / 28卷 / 19期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1080/00397919808004917

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

EF5 (a 2-nitroimidazole containing an N-(pentafluoropropyl) acetamide substituent) is a very sensitive probe for quantifying the amount of hypoxia within cells; a much improved, short step, synthetic procedure is described for EF5, whose X-ray structure is also presented.

引用

页码：3701 / 3709

页数：9

共 17 条

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