MicroRNA-145 induces apoptosis of glioma cells by targeting BNIP3 and Notch signaling

被引：47
作者：
Du, Yan [1 ,2 ]
Li, Juan [3 ]
Xu, Tao [1 ,2 ]
Zhou, Dan-Dan [1 ,2 ]
Zhang, Lei [1 ,2 ]
Wang, Xiao [4 ]
机构：
[1] Anhui Med Univ, Anhui Inst Innovat Drugs, Anhui Prov Key Lab Major Autoimmune Dis, Sch Pharm, Hefei 230032, Anhui, Peoples R China
[2] Anhui Med Univ, Inst Liver Dis, Hefei 230032, Anhui, Peoples R China
[3] Anhui Prov Hosp, Hefei 230032, Anhui, Peoples R China
[4] Anhui Med Univ, Affiliated Hosp 1, Dept Radiol, Hefei 230022, Anhui, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 37期
基金：
安徽省自然科学基金;
关键词：
malignant gliomas; BNIP3; miR-145; apoptosis; notch signaling; HUMAN GLIOBLASTOMA CELLS; BCL-2; FAMILY-MEMBER; STEM-CELLS; TUMOR-SUPPRESSOR; SELF-RENEWAL; C-MYC; HYPOXIA; DEATH; EXPRESSION; MIGRATION;
D O I：
10.18632/oncotarget.18604
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs (miRNAs) are involved in the pathogenesis of various human cancers. Here we show that miR-145 expression is decreased in human glioma samples, rat glioma tissues, and glioma cell lines, while expression of BNIP3 is increased. Overexpression of miR-145 or suppression of BNIP3 induced glioma cell apoptosis. BNIP3 is localized in the nucleus in glioma cells, and miR-145 inhibits BNIP3 expression by binding to the 3' untranslated region of its mRNA. Interestingly, miR-145 and BNIP3 regulate glioma cell apoptosis by modulating Notch signaling. These results indicate that miR-145 increases glioma cell apoptosis by inhibiting BNIP3 and Notch signaling, and suggest that miR-145 may serve as a novel therapeutic target for malignant glioma.
引用
收藏
页码：61510 / 61527
页数：18
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