MicroRNA-145 induces apoptosis of glioma cells by targeting BNIP3 and Notch signaling

被引：47

作者：

Du, Yan ^{[1
,2
]}

Li, Juan ^{[3
]}

Xu, Tao ^{[1
,2
]}

Zhou, Dan-Dan ^{[1
,2
]}

Zhang, Lei ^{[1
,2
]}

Wang, Xiao ^{[4
]}

机构：

[1] Anhui Med Univ, Anhui Inst Innovat Drugs, Anhui Prov Key Lab Major Autoimmune Dis, Sch Pharm, Hefei 230032, Anhui, Peoples R China

[2] Anhui Med Univ, Inst Liver Dis, Hefei 230032, Anhui, Peoples R China

[3] Anhui Prov Hosp, Hefei 230032, Anhui, Peoples R China

[4] Anhui Med Univ, Affiliated Hosp 1, Dept Radiol, Hefei 230022, Anhui, Peoples R China

来源：

ONCOTARGET | 2017年 / 8卷 / 37期

基金：

安徽省自然科学基金;

关键词：

malignant gliomas; BNIP3; miR-145; apoptosis; notch signaling; HUMAN GLIOBLASTOMA CELLS; BCL-2; FAMILY-MEMBER; STEM-CELLS; TUMOR-SUPPRESSOR; SELF-RENEWAL; C-MYC; HYPOXIA; DEATH; EXPRESSION; MIGRATION;

D O I：

10.18632/oncotarget.18604

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are involved in the pathogenesis of various human cancers. Here we show that miR-145 expression is decreased in human glioma samples, rat glioma tissues, and glioma cell lines, while expression of BNIP3 is increased. Overexpression of miR-145 or suppression of BNIP3 induced glioma cell apoptosis. BNIP3 is localized in the nucleus in glioma cells, and miR-145 inhibits BNIP3 expression by binding to the 3' untranslated region of its mRNA. Interestingly, miR-145 and BNIP3 regulate glioma cell apoptosis by modulating Notch signaling. These results indicate that miR-145 increases glioma cell apoptosis by inhibiting BNIP3 and Notch signaling, and suggest that miR-145 may serve as a novel therapeutic target for malignant glioma.

引用

页码：61510 / 61527

页数：18

共 38 条

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