Breast cancer: origins and evolution

被引：445

作者：

Polyak, Kornelia

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2007年 / 117卷 / 11期

关键词：

D O I：

10.1172/JCI33295

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Breast cancer is not a single disease, but rather is composed of distinct subtypes assosiated with different clinical outcomes. understanding this heterogeneity is key for the development of targeted cancer-preventative and -therapeutic interventions. Current models explaining inter- and intr- tumoral diversity are the cancer stem cell and the clonal evolution hypothesis. Although tumor initiation and progression are predominantly driven by acquired genetic alterations, recent data implicate a role for microenvironmental and epigenetic changes as well. Comprehensive unbiased studies of tumors and patient populations have significantly advanced our molecular understanding of breast cancer, but translating these findings into clinical practice remains a challenge.

引用

页码：3155 / 3163

页数：9

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