Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum

被引：462

作者：

Jin, K ^{[1
]}

Sun, YJ ^{[1
]}

Xie, L ^{[1
]}

Peel, A ^{[1
]}

Mao, XO ^{[1
]}

Batteur, S ^{[1
]}

Greenberg, DA ^{[1
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2003年 / 24卷 / 01期

关键词：

D O I：

10.1016/S1044-7431(03)00159-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pathological processes, including cerebral ischemia, can enhance neurogenesis in the adult brain, but the fate of the newborn neurons that are produced and their role in brain repair are obscure. To determine if ischemia-induced neuronal proliferation is associated with migration of nascent neurons toward ischemic lesions, we mapped the migration of cells labeled by cell proliferation markers and antibodies against neuronal marker proteins, for up to 2 weeks after a 90-min episode of focal cerebral ischemia caused by occlusion of the middle cerebral artery. Doublecortin-immunoreactive cells in the rostral subventricular zone, but not the dentate gyrus, migrated into the ischemic penumbra of the adjacent striatum and, via the rostral migratory stream and lateral cortical stream, into the penumbra of ischemic cortex. These results indicate that after cerebral ischemia, new neurons are directed toward sites of brain injury, where they might be in a position to participate in brain repair and functional recovery. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：171 / 189

页数：19

共 66 条

[1] AUTORADIOGRAPHIC AND HISTOLOGICAL EVIDENCE OF POSTNATAL HIPPOCAMPAL NEUROGENESIS IN RATS [J].