Role of histone and DNA methylation in gene regulation

被引：150

作者：

Vaillant, Isabelle ^{[1
]}

Paszkowski, Jerzy ^{[1
]}

机构：

[1] Univ Geneva, Lab Plant Genet, CH-1211 Geneva 4, Switzerland

来源：

CURRENT OPINION IN PLANT BIOLOGY | 2007年 / 10卷 / 05期

关键词：

D O I：

10.1016/j.pbi.2007.06.008

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Transcription is known to be regulated by given chromatin states, distinguished as transcriptionally active euchromatin and silent heterochromatin. In plants, silencing in heterochromatin is associated with hypermethylation of DNA and specific covalent modifications of histone H3. Several lines of evidence have suggested that maintenance of DNA methylation patterns at CG sequences is responsible for the formation of stable and thus heritable activity states termed epialleles. By contrast, histone modification and DNA methylation outside CGs confer the flexibility of transcriptional regulation necessary for plant development and adaptive responses to the environment. Recent studies have refined our understanding of the biological significance of and the molecular mechanisms involved in the interplay between DNA and histone H3 methylation.

引用

页码：528 / 533

页数：6

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