SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

被引：113

作者：

Sancho-Shimizu, Vanessa ^{[1
,2
]}

Brodin, Petter ^{[3
]}

Cobat, Aurelie ^{[4
,5
,6
]}

Biggs, Catherine M. ^{[7
,8
]}

Toubiana, Julie ^{[9
,10
]}

Lucas, Carrie L. ^{[11
]}

Henrickson, Sarah E. ^{[12
,13
]}

Belot, Alexandre ^{[14
,15
]}

Tangye, Stuart G. ^{[16
,17
]}

Milner, Joshua D. ^{[18
]}

Levin, Michael ^{[1
,2
]}

Abel, Laurent ^{[4
,5
,6
]}

Bogunovic, Dusan ^{[19
]}

Casanova, Jean-Laurent ^{[4
,5
,6
,20
]}

Zhang, Shen-Ying ^{[4
,5
,6
]}

机构：

[1] Imperial Coll London, Dept Paediat Infect Dis & Virol, London, England

[2] Imperial Coll London, Ctr Paediat & Child Hlth, Fac Med, London, England

[3] Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Stockholm, Sweden

[4] Rockefeller Univ, Rockefeller Branch, St Giles Lab Human Genet Infect Dis, New York, NY USA

[5] Necker Hosp Sick Children, Inst Natl St & Rech Med, Necker Branch, Lab Human Genet Infect Dis, Paris, France

[6] Univ Paris, Imagine Inst, Paris, France

[7] Univ British Columbia, Dept Pediat, Vancouver, BC, Canada

[8] British Columbia Childrens Hosp, Res Inst, Vancouver, BC, Canada

[9] Univ Paris, Assistance Publ Hosp Paris, Necker Hosp Sick Children, Dept Gen Pediat & Pediat Infect Dis, Paris, France

[10] Inst Pasteur, Biodivers & Epidemiol Bacterial Pathogens, Paris, France

[11] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT USA

[12] Childrens Hosp Philadelphia, Div Allergy Immunol, Philadelphia, PA USA

[13] Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA USA

[14] Univ Lyon, Univ Claude Bernard, Inst Natl St & Rech Med, Ctr Int Rech Infectiol, Lyon 1, Lyon, France

[15] Hosp Civils Lyon, Natl Reference Ctr Rheumat, Dermatol Unit, Autoimmune & System Dis Children RAISE, Lyon, France

[16] Inst Med Res, Darlinghurst, NSW, Australia

[17] Univ New South Wales Sydney, St Vincents Clin Sch, Fac Med, Sydney, NSW, Australia

[18] Columbia Univ, Irving Med Ctr, Dept Pediat, New York, NY USA

[19] Precis Immunol Inst, Mindich Child Hlth & Dev Inst, Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY USA

[20] Howard Hughes Med Inst, New York, NY USA

[21] Multisystem Inflammatory Syndrome Children, COVID Human Genet Effort, Itasca, IL USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2021年 / 218卷 / 06期

基金：

英国医学研究理事会; 美国国家卫生研究院; 英国科研创新办公室;

关键词：

MULTISYSTEM INFLAMMATORY SYNDROME; GENOME-WIDE ASSOCIATION; HUMAN CORONAVIRUS NL63; PIMS-TS; SUSCEPTIBILITY LOCI; CORONARY ANEURYSMS; CHILDREN; COVID-19; INFECTION; SHOCK;

D O I：

10.1084/jem.20210446

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2 is the trigger for MIS-C, which typically occurs about 1 mo after infection. These findings support the hypothesis of viral triggers for the various forms of classic KD. We further suggest that rare inborn errors of immunity (IEIs) altering the immune response to SARS-CoV-2 may underlie the pathogenesis of MIS-C in some children. The discovery of monogenic IEIs underlying MIS-C would shed light on its pathogenesis, paving the way for a new genetic approach to classic KD, revisited as a heterogeneous collection of IEIs to viruses.

引用

页数：24

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