Towards disposable sensors for drug quality control: Dextromethorphan screen-printed electrodes

被引：25

作者：

Khaled, Elmorsy ^{[1
]}

Hassan, H. N. A. ^{[1
]}

Mohamed, Gehad G. ^{[2
]}

Seleim, Aly Eldin A. ^{[3
]}

机构：

[1] Natl Res Ctr, Microanal Lab, Giza 14211, Egypt

[2] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt

[3] Cairo Univ, Fac Med, Crit Care Dept, Giza 12613, Egypt

来源：

DRUG TESTING AND ANALYSIS | 2010年 / 2卷 / 9-10期

关键词：

disposable screen-printed carbon electrode; potentiometry; dextromethorphan; flow injection analysis (FIA); pharmaceutical preparations; ION-SELECTIVE ELECTRODES; INJECTION POTENTIOMETRIC DETERMINATION; CARBON-PASTE ELECTRODES; PVC ELECTRODES; MEMBRANE; URINE;

D O I：

10.1002/dta.159

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple, rapid, reliable, and reproducible method for mass production of disposable sensors using screen-printing technology is described. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrode was used as dextromethorphan (DXM) sensor. The proposed sensors worked satisfactorily in the concentration range from 10(-5) to 10(-2) mol L-1 with detection limit reaching 6 x 10(-6) mol L-1 and adequate shelf life of 8 months. DXM was determined in pharmaceutical formulations under batch and flow injection analysis (FIA) conditions with sampling output 120 h(-1). Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：424 / 429

页数：6

共 32 条

[11] Recent developments in the design and application of screen-printed electrochemical sensors for biomedical, environmental and industrial analyses [J].