Towards disposable sensors for drug quality control: Dextromethorphan screen-printed electrodes

被引：25
作者：
Khaled, Elmorsy [1 ]
Hassan, H. N. A. [1 ]
Mohamed, Gehad G. [2 ]
Seleim, Aly Eldin A. [3 ]
机构：
[1] Natl Res Ctr, Microanal Lab, Giza 14211, Egypt
[2] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt
[3] Cairo Univ, Fac Med, Crit Care Dept, Giza 12613, Egypt
来源：
DRUG TESTING AND ANALYSIS | 2010年 / 2卷 / 9-10期
关键词：
disposable screen-printed carbon electrode; potentiometry; dextromethorphan; flow injection analysis (FIA); pharmaceutical preparations; ION-SELECTIVE ELECTRODES; INJECTION POTENTIOMETRIC DETERMINATION; CARBON-PASTE ELECTRODES; PVC ELECTRODES; MEMBRANE; URINE;
D O I：
10.1002/dta.159
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple, rapid, reliable, and reproducible method for mass production of disposable sensors using screen-printing technology is described. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi-electrode potentiometric strip containing both working and reference electrode was used as dextromethorphan (DXM) sensor. The proposed sensors worked satisfactorily in the concentration range from 10(-5) to 10(-2) mol L-1 with detection limit reaching 6 x 10(-6) mol L-1 and adequate shelf life of 8 months. DXM was determined in pharmaceutical formulations under batch and flow injection analysis (FIA) conditions with sampling output 120 h(-1). Copyright (C) 2010 John Wiley & Sons, Ltd.
引用
收藏
页码：424 / 429
页数：6
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