Effects of in utero and lactational exposure to the no-observed-adverse-effect level (NOAEL) dose of the neonicotinoid clothianidin on the reproductive organs of female mice

被引：20

作者：

Kitauchi, Sayaka ^{[1
]}

Maeda, Mizuki ^{[1
]}

Hirano, Tetsushi ^{[3
]}

Ikenaka, Yoshinori ^{[4
,5
,6
]}

Nishi, Misaki ^{[1
]}

Shoda, Asuka ^{[1
]}

Murata, Midori ^{[1
]}

Mantani, Youhei ^{[2
]}

Yokoyama, Toshifumi ^{[1
]}

Tabuchi, Yoshiaki ^{[3
]}

Hoshi, Nobuhiko ^{[1
]}

机构：

[1] Kobe Univ, Grad Sch Agr Sci, Dept Anim Sci, Lab Anim Mol Morphol,Nada Ku, 1-1 Rokkodai, Kobe, Hyogo 6578501, Japan

[2] Kobe Univ, Grad Sch Agr Sci, Dept Anim Sci, Lab Histophysiol,Nada Ku, 1-1 Rokkodai, Kobe, Hyogo 6578501, Japan

[3] Toyama Univ, Life Sci Res Ctr, 2630 Sugitani, Toyama 9300194, Japan

[4] Hokkaido Univ, Fac Vet Med, Dept Environm Vet Sci, Lab Toxicol,Kita Ku, Kita 18,Nishi 9, Sapporo, Hokkaido 0600818, Japan

[5] Hokkaido Univ, Vet Teaching Hosp, Fac Vet Med, Translat Res Unit,Kita Ku, Kita 18,Nishi 9, Sapporo, Hokkaido 0600818, Japan

[6] North West Univ, Unit Environm Sci & Management, Water Res Grp, 11 Hoffman St, ZA-2531 Potchefstroom, South Africa

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2021年 / 83卷 / 04期

关键词：

clothianidin; developmental stage; DOHaD (developmental origins of health and diseases); female mice; in utero and lactational exposure; OXIDATIVE STRESS; INSECTICIDES; BEHAVIOR; STEROIDOGENESIS; PROGESTERONE; DINOTEFURAN; PESTICIDE; PREGNANCY; ELEVATION; SYSTEM;

D O I：

10.1292/jvms.21-0014

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Recently, developmental exposure to clothianidin (CLO) has been shown to cause reproductive toxicity in male mice, but the effects in female mice remain to be clarified. Pregnant C57BL/6N mice were given a no-observed-adverse-effect-level (NOAEL) dose of CLO until weaning. We then examined ovaries of 3- or 10-week-old female offspring. In the CLO-administered group, morphological changes, a decrease in the immunoreactivity of the antioxidant enzyme glutathione peroxidase 4 (GPx4), and activation of genes in the steroid hormone biosynthesis pathway were observed in 3-week-old mice, and decreases of GPx4 immunoreactivity, 17OH-progesterone and corticosterone levels were observed in 10-week-old mice, along with high rates of infanticide and severe neglect, providing new evidence that developmental exposure to CLO affects juvenile and adult mice differently.

引用

页码：746 / 753

页数：8

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