Association between PRODH and schizophrenia is not confirmed

被引：40
作者：
Williams, HJ
Williams, N
Spurlock, G
Norton, N
Ivanov, D
McCreadie, RG
Preece, A
Sharkey, V
Jones, S
Zammit, S
Nikolov, I
Kehaiov, I
Thapar, A
Murphy, KC
Kirov, G
Owen, MJ
O'Donovan, MC
机构：
[1] Univ Wales Coll Med, Dept Med Psychol, Cardiff CF4 4XN, S Glam, Wales
[2] Crichton Royal Hosp, Dept Clin Res, Dumfries, Scotland
[3] Med Univ Sofia, Sofia, Bulgaria
[4] Royal Coll Surgeons Ireland, Educ & Res Ctr, Beaumont Hosp, Dublin 2, Ireland
来源：
MOLECULAR PSYCHIATRY | 2003年 / 8卷 / 07期
关键词：
D O I：
10.1038/sj.mp.4001276
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Previous studies show that genetic variation within the proline dehydrogenase gene (PRODH) increases risk of developing schizophrenia. This is of particular interest since PRODH maps to chromosome 22q11, deletion of which is a strong risk factor for schizophrenia. The authors examined this claim using samples with power of ∼0.99, but failed to obtain evidence in support of the hypothesis. Given the high power to replicate the previous findings, the data suggest that genetic variation in PRODH is unlikely to be associated with increased risk of schizophrenia.
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收藏
页码：644 / 645
页数：2
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