Childhood-onset craniopharyngioma: latest insights into pathology, diagnostics, treatment, and follow-up

被引:45
作者
Bogusz, Agnieszka [1 ,2 ]
Mueller, Hermann L. [1 ]
机构
[1] Klinikum Oldenburg AoR, Dept Pediat & Pediat Hematol Oncol, Med Campus Univ Oldenburg,Rahel Straus Str 10, D-26133 Oldenburg, Germany
[2] Childrens Mem Hlth Inst, Dept Endocrinol & Diabetol, Warsaw, Poland
关键词
Craniopharyngioma; hypothalamus; pituitary; obesity; irradiation; neurosurgery; quality of life; QUALITY-OF-LIFE; BODY-MASS INDEX; TRIAL KRANIOPHARYNGEOM 2000; LONG-TERM SURVIVORS; HYPOTHALAMIC OBESITY; INTRATUMORAL CHEMOTHERAPY; CYSTIC CRANIOPHARYNGIOMA; COGNITIVE PERFORMANCE; SURGICAL-MANAGEMENT; FUNCTIONAL-CAPACITY;
D O I
10.1080/14737175.2018.1528874
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Introduction: Childhood-onset craniopharyngiomas are rare embryonic tumors of low-grade histological malignancy. Severe obesity, physical fatigue, and psychosocial deficits due to hypothalamic tumor involvement have negative impact on quality of life. Initial pretreatment involvement of hypothalamic structures and/or treatment-related lesions result in sequelae clinically associated with impaired social and physical functionality and severe neuroendocrine deficiencies. Overall and progression-free survival rates are not associated with the degree of surgical resection. However, reduced overall survival rates were observed in patients with primary hypothalamic tumor involvement.Areas covered: This review discusses new perspectives on diagnostics, treatment, and follow-up of patients with childhood-onset craniopharyngioma, which were mostly published after 2010 and presented at the 5th International Multidisciplinary Postgraduate Course on Childhood Craniopharyngioma, 19-22 April 2018, at Bad Zwischenahn, Germany.Expert commentary: Percutaneous radio-oncological treatment options are effective in prevention of relapses and tumor progressions. Initial experience with proton beam therapy in childhood-onset craniopharyngioma patients shows promising results in terms of more protective radiological treatment. Recent reports on the molecular pathogenesis of craniopharyngioma open perspectives on the possibility of testing novel treatments targeting pathogenic pathways. As long as effective treatment options for hypothalamic syndrome are not available, hypothalamus-sparing treatment strategies are recommended.
引用
收藏
页码:793 / 806
页数:14
相关论文
共 112 条
[1]  
Ahmet A, 2006, J PEDIATR ENDOCR MET, V19, P121
[2]   Proton Therapy for Craniopharyngioma - An Early Report from a Single European Centre [J].
Ajithkumar, T. ;
Mazhari, A. -L. ;
Stickan-Verfuerth, M. ;
Kramer, P. -H. ;
Fuentes, C. -S. ;
Lambert, J. ;
Thomas, H. ;
Mueller, H. ;
Fleischhack, G. ;
Timmermann, B. .
CLINICAL ONCOLOGY, 2018, 30 (05) :307-316
[3]   Child dermoid cyst mimicking a craniopharyngioma: the benefit of MRI T2-weighted diffusion sequence [J].
Amelot, Aymeric ;
Borha, Alin ;
Calmon, Raphael ;
Barbet, Patrick ;
Puget, Stephanie .
CHILDS NERVOUS SYSTEM, 2018, 34 (02) :359-362
[4]   Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pathway as a novel therapeutic target [J].
Apps, John R. ;
Carreno, Gabriela ;
Mario Gonzalez-Meljem, Jose ;
Haston, Scott ;
Guiho, Romain ;
Cooper, Julie E. ;
Manshaei, Saba ;
Jani, Nital ;
Holsken, Annett ;
Pettorini, Benedetta ;
Beynon, Robert J. ;
Simpson, Deborah M. ;
Fraser, Helen C. ;
Hong, Ying ;
Hallang, Shirleen ;
Stone, Thomas J. ;
Virasami, Alex ;
Donson, Andrew M. ;
Jones, David ;
Aquilina, Kristian ;
Spoudeas, Helen ;
Joshi, Abhijit R. ;
Grundy, Richard ;
Storer, Lisa C. D. ;
Korbonits, Marta ;
Hilton, David A. ;
Tossell, Kyoko ;
Thavaraj, Selvam ;
Ungless, Mark A. ;
Gil, Jesus ;
Buslei, Rolf ;
Hankinson, Todd ;
Hargrave, Darren ;
Goding, Colin ;
Andoniadou, Cynthia L. ;
Brogan, Paul ;
Jacques, Thomas S. ;
Williams, Hywel J. ;
Martinez-Barbera, Juan Pedro .
ACTA NEUROPATHOLOGICA, 2018, 135 (05) :757-777
[5]  
Bartels Ute, 2012, Front Endocrinol (Lausanne), V3, P39, DOI 10.3389/fendo.2012.00039
[6]   DOSIMETRIC COMPARISON OF THREE-DIMENSIONAL CONFORMAL PROTON RADIOTHERAPY, INTENSITY-MODULATED PROTON THERAPY, AND INTENSITY-MODULATED RADIOTHERAPY FOR TREATMENT OF PEDIATRIC CRANIOPHARYNGIOMAS [J].
Boehling, Nicholas S. ;
Grosshans, David R. ;
Bluett, Jaques B. ;
Palmer, Matthew T. ;
Song, Xiaofei ;
Amos, Richard A. ;
Sahoo, Narayan ;
Meyer, Jeffrey J. ;
Mahajan, Anita ;
Woo, Shiao Y. .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2012, 82 (02) :643-652
[7]   Papillary craniopharyngioma in a 4-year-old girl with BRAF V600E mutation: a case report and review of the literature [J].
Borrill, R. ;
Cheesman, E. ;
Stivaros, S. ;
Kamaly-Asl, I. D. ;
Gnanalingham, K. ;
Kilday, John-Paul .
CHILDS NERVOUS SYSTEM, 2019, 35 (01) :169-173
[8]   Preclinical transgenic and patient-derived xenograft models recapitulate the radiological features of human adamantinomatous craniopharyngioma [J].
Boult, Jessica K. R. ;
Apps, John R. ;
Hoelsken, Annett ;
Hutchinson, J. Ciaran ;
Carreno, Gabriela ;
Danielson, Laura S. ;
Smith, Laura M. ;
Baeuerle, Tobias ;
Buslei, Rolf ;
Buchfelder, Michael ;
Virasami, Alex K. ;
Koers, Alexander ;
Arthurs, Owen J. ;
Jacques, Thomas S. ;
Chesler, Louis ;
Martinez-Barbera, Juan Pedro ;
Robinson, Simon P. .
BRAIN PATHOLOGY, 2018, 28 (04) :475-483
[9]   Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy [J].
Brastianos, Priscilla K. ;
Shankar, Ganesh M. ;
Gill, Corey M. ;
Taylor-Weiner, Amaro ;
Nayyar, Naema ;
Panka, David J. ;
Sullivan, Ryan J. ;
Frederick, Dennie T. ;
Abedalthagafi, Malak ;
Jones, Pamela S. ;
Dunn, Ian F. ;
Nahed, Brian V. ;
Romero, Javier M. ;
Louis, David N. ;
Getz, Gad ;
Cahill, Daniel P. ;
Santagata, Sandro ;
Curry, William T., Jr. ;
Barker, Fred G., II .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2016, 108 (02)
[10]   Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas [J].
Brastianos, Priscilla K. ;
Taylor-Weiner, Amaro ;
Manley, Peter E. ;
Jones, Robert T. ;
Dias-Santagata, Dora ;
Thorner, Aaron R. ;
Lawrence, Michael S. ;
Rodriguez, Fausto J. ;
Bernardo, Lindsay A. ;
Schubert, Laura ;
Sunkavalli, Ashwini ;
Shillingford, Nick ;
Calicchio, Monica L. ;
Lidov, Hart G. W. ;
Taha, Hala ;
Martinez-Lage, Maria ;
Santi, Mariarita ;
Storm, Phillip B. ;
Lee, John Y. K. ;
Palmer, James N. ;
Adappa, Nithin D. ;
Scott, R. Michael ;
Dunn, Ian F. ;
Laws, Edward R., Jr. ;
Stewart, Chip ;
Ligon, Keith L. ;
Hoang, Mai P. ;
Van Hummelen, Paul ;
Hahn, William C. ;
Louis, David N. ;
Resnick, Adam C. ;
Kieran, Mark W. ;
Getz, Gad ;
Santagata, Sandro .
NATURE GENETICS, 2014, 46 (02) :161-U100