Immunotherapy: a potential adjunctive treatment for fungal infection

被引：25
作者：
Kullberg, Bart-Jan [1 ]
van de Veerdonk, Frank
Netea, Mihai G.
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Med, NL-6500 HB Nijmegen, Netherlands
来源：
CURRENT OPINION IN INFECTIOUS DISEASES | 2014年 / 27卷 / 06期
关键词：
candidiasis; disease susceptibility; fungal infections; immunogenetics; immunotherapy; CHRONIC MUCOCUTANEOUS CANDIDIASIS; INVASIVE CANDIDIASIS; INTERFERON-GAMMA; STAT1; MUTATIONS; IL-17; IMMUNITY; INBORN-ERRORS; SUSCEPTIBILITY; CANDIDEMIA; ALBICANS; EPIDEMIOLOGY;
D O I：
10.1097/QCO.0000000000000105
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Purpose of reviewInvasive and mucosal candidiasis are associated with major morbidity in patients with inappropriate host defence mechanisms. This review focuses on recent studies elucidating the immune response against candidiasis and possible immunotherapeutic approaches.Recent findingsThe last year has seen substantial advances in understanding antifungal immunity. The role of pattern recognition receptors and the Th1 and Th17 immune pathways has been further elucidated. The first genome-wide studies have identified new risk factors for candidaemia. Trials of adjuvant immunotherapy for fungal infections have provided directions for the future.SummaryUnderstanding the fungal pathogenesis and the induction of protective antifungal adaptive immunity has advanced the development of immunotherapeutic strategies and vaccines against invasive and mucosal candidiasis.
引用
收藏
页码：511 / 516
页数：6
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