ViVar: A Comprehensive Platform for the Analysis and Visualization of Structural Genomic Variation

被引:43
作者
Sante, Tom [1 ]
Vergult, Sarah [1 ]
Volders, Pieter-Jan [1 ]
Kloosterman, Wigard P. [2 ]
Trooskens, Geert [3 ]
De Preter, Katleen [1 ]
Dheedene, Annelies [1 ]
Speleman, Frank [1 ]
De Meyer, Tim [3 ]
Menten, Bjorn [1 ]
机构
[1] Univ Ghent, Fac Med & Hlth Sci, Ctr Med Genet, B-9000 Ghent, Belgium
[2] Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
[3] Univ Ghent, Fac Biosci Engn, BioBix, B-9000 Ghent, Belgium
基金
比利时弗兰德研究基金会;
关键词
DATABASE; REARRANGEMENTS; SEQUENCES; ALIGNMENT; TOOL;
D O I
10.1371/journal.pone.0113800
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Structural genomic variations play an important role in human disease and phenotypic diversity. With the rise of high-throughput sequencing tools, mate-pair/paired-end/single-read sequencing has become an important technique for the detection and exploration of structural variation. Several analysis tools exist to handle different parts and aspects of such sequencing based structural variation analyses pipelines. A comprehensive analysis platform to handle all steps, from processing the sequencing data, to the discovery and visualization of structural variants, is missing. The ViVar platform is built to handle the discovery of structural variants, from Depth Of Coverage analysis, aberrant read pair clustering to split read analysis. ViVar provides you with powerful visualization options, enables easy reporting of results and better usability and data management. The platform facilitates the processing, analysis and visualization, of structural variation based on massive parallel sequencing data, enabling the rapid identification of disease loci or genes. ViVar allows you to scale your analysis with your work load over multiple (cloud) servers, has user access control to keep your data safe and is easy expandable as analysis techniques advance.
引用
收藏
页数:12
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