Cell Membrane-Camouflaged Colloid Motors for Biomedical Applications

被引：52

作者：

Gao, Changyong ^{[1
]}

Lin, Zhihua ^{[1
]}

Lin, Xiankun ^{[1
]}

He, Qiang ^{[1
]}

机构：

[1] Harbin Inst Technol, Micro Nano Technol Res Ctr, State Key Lab Robot & Syst, Key Lab Microsyst & Microstruct Mfg, 2 Yikuang St, Harbin 150080, Peoples R China

来源：

ADVANCED THERAPEUTICS | 2018年 / 1卷 / 05期

基金：

中国国家自然科学基金;

关键词：

biomedical applications; cell membranes; colloid motors; self-propulsion; OVERCOMING BIOLOGICAL BARRIERS; PROPELLED MICRO-/NANOMOTORS; CONTROLLED DRUG-DELIVERY; ERYTHROCYTE-MEMBRANE; AUTONOMOUS MOVEMENT; MICROMOTORS DRIVEN; JANUS MICROMOTORS; RECENT PROGRESS; CANCER; NANOPARTICLES;

D O I：

10.1002/adtp.201800056

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Natural cell membrane-camouflaged colloid motors can not only convert the surrounding environmental energy into directed movement but also possess the functions of natural cell membranes. They can autonomously move and are guided by exogenous (e.g., chemical fuel, light, magnetic field, and ultrasound) and endogenous (i.e., chemotaxis) stimuli. These biointerfacing colloid motors with efficient drug loading/transporting capacity, prolonged blood circulation, and antibiofouling and specific targeting abilities are expected to open up opportunities for various biomedical applications and are recognized as the next-generation therapeutic systems. In this progress report, the authors highlight the recent progress in research on cell membrane-coated colloid motors, as well as their potential for biomedical applications. The limitations and challenges of these colloid motors for in vivo applications are also addressed.

引用

页数：15

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