Polysaccharides from Dendrobium officinale inhibit bleomycin-induced pulmonary fibrosis via the TGFβ1-Smad2/3 axis

被引：30

作者：

Chen, Jianhui ^{[1
,2
]}

Lu, Junhui ^{[2
]}

Wang, Baolan ^{[3
]}

Zhang, Xiaolei ^{[4
]}

Huang, Qiuyang ^{[5
]}

Yuan, Jun ^{[5
]}

Hao, Hairong ^{[2
]}

Chen, Xing ^{[5
]}

Zhi, Junchao ^{[5
]}

Zhao, Lan ^{[6
]}

Chu, Haiqing ^{[6
]}

机构：

[1] Tongji Univ, Sch Med, Shanghai 200092, Peoples R China

[2] Xuzhou Med Univ, Affiliated Huaian Hosp, Huaian 223002, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Huaian Peoples Hosp 1, Huaian 223300, Jiangsu, Peoples R China

[4] Jiangsu Vocat Coll Nursing, Huaian 223003, Jiangsu, Peoples R China

[5] Jiangsu Key Lab Reg Resource Exploitat & Med Res, Huaian 223003, Jiangsu, Peoples R China

[6] Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Resp Med, Shanghai 200433, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2018年 / 118卷

关键词：

Polysaccharides from Dendrobium officinale; Pulmonary fibrosis; TGF beta 1-Smad2/3 axis; THORACIC-SOCIETY; SURVIVAL; INFLAMMATION; THERAPY; ROLES; ALPHA; MICE;

D O I：

10.1016/j.ijbiomac.2018.07.056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polysaccharides from Dendrobium officinale (PDO) have been found to elicit significant benefits for patients with fibrotic diseases. However, there are no reports on treatment of idiopathic pulmonary fibrosis (IPF) using PDO. The aim of this paper was to investigate the therapeutic effects of PDO on IPF and its underlying mechanisms. Our data showed that PDO significantly ameliorated indices for both pulmonary inflammation and fibrosis in a bleomycin (BLM)-induced pulmonary fibrosis model in rats, which was associated with inactivation of transforming growth factor beta 1 (TGH beta 1)-Smad2/3 signaling pathway. Moreover, PDO effectively blocked TGF beta 1-induced transformation of rat alveolar epithelial type II cells into myofibroblasts, with the inhibition of total Smad2/3, pSmad2/3, collagen I and fibronectin protein expression in a dose-dependent manner in vitro. Therefore, PDO may represent as a promising candidate biomacromolecule drug for the safe and effective therapy of IPF. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：2163 / 2175

页数：13

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