MicroRNAs: Novel Molecular Targets and Response Modulators of Statin Therapy

被引：54

作者：

Mohajeri, Mohammad ^{[1
]}

Banach, Maciej ^{[2
,3
,4
]}

Atkin, Stephen L. ^{[5
]}

Butler, Alexandra E. ^{[6
]}

Ruscica, Massimiliano ^{[7
]}

Watts, Gerald F. ^{[8
,9
]}

Sahebkar, Amirhossein ^{[10
,11
,12
]}

机构：

[1] Mashhad Univ Med Sci, Dept Med Biotechnol, Mashhad, Iran

[2] WAM Univ Hosp Lodz, Med Univ Lodz, Dept Hypertens, Zeromskiego 113, Lodz, Poland

[3] PMMHRI, Lodz, Poland

[4] Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland

[5] Weill Cornell Med Qatar, Doha, Qatar

[6] Qatar Biomed Res Inst, Diabet Res Ctr, Doha, Qatar

[7] Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy

[8] Royal Perth Hosp, Lipid Disorders Clin, Dept Cardiol, Perth, WA, Australia

[9] Univ Western Australia, Sch Med, Fac Hlth & Med Sci, Perth, WA, Australia

[10] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Res Ctr, Mashhad, Iran

[11] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran

[12] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2018年 / 39卷 / 11期

关键词：

ENDOTHELIAL PROGENITOR CELLS; LOW-DENSITY-LIPOPROTEIN; RECEPTOR; 4; SIGNAL; CARDIOVASCULAR RISK; OXIDATIVE STRESS; DOWN-REGULATION; EMERGING ROLES; T-LYMPHOCYTES; EXPRESSION; ATORVASTATIN;

D O I：

10.1016/j.tips.2018.09.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cardiovascular disease (CVD) is a major cause of death globally. Addressing cardiovascular risk factors, particularly dyslipidemia, represents the most robust clinical strategy towards reducing the CVD burden. Statins inhibit 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and represent the main therapeutic approach for lowering cholesterol and reducing plaque formation/rupture. The protective effects of statins extend beyond lowering cholesterol. MicroRNAs (miRNAs or miRs), small noncoding regulatory RNAs, likely mediate the positive pleiotropic effects of statins via modulation of lipid metabolism, enhancement of endothelial function, inhibition of inflammation, improvement of plaque stability, and immune regulation. miRNAs are implicated in statin-related interindividual variations in therapeutic response, directly via HMG-CoA reductase, or indirectly through targeting cytochrome P450 3A (CYP3A) functionality and proprotein convertase subtilisin/kexin type9 (PCSK9) biology.

引用

页码：967 / 981

页数：15

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