The Changing Landscape of Alopecia Areata: The Translational Landscape

被引：19

作者：

Wang, Etienne C. E. ^{[1
]}

Christiano, Angela M. ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Russ Berrie Med Pavil, New York, NY 10032 USA

来源：

ADVANCES IN THERAPY | 2017年 / 34卷 / 07期

关键词：

Alopecia areata; Basic science; Genetics; Immunodulation; Translational research; GENOME-WIDE ASSOCIATION; OF-THE-LITERATURE; C3H/HEJ MICE; RHEUMATOID-ARTHRITIS; HAIR LOSS; CELLS; SIMVASTATIN/EZETIMIBE; POLYMORPHISMS; RUXOLITINIB; AUTOANTIGEN;

D O I：

10.1007/s12325-017-0540-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Recent genetic and preclinical studies have increased our understanding of the immunopathogenesis of alopecia areata (AA). This has allowed expedited development of targeted therapies for the treatment of AA, and a paradigm shift in our approach and understanding of autoimmunity and the hair follicle. The synergy between preclinical studies, animal models, and translational studies has led to unprecedented advances in the treatment options for AA, ultimately benefiting patients who have had little recourse. In this review, we summarize the scientific field of contemporary AA research, and look forward to potential new technologies and developments.

引用

页码：1586 / 1593

页数：8

共 50 条

[1]

Ali A, 2010, J DRUGS DERMATOL, V9, P62

[2] Reflectance Confocal Microscopy of the Yellow Dot Pattern in Alopecia Areata [J].

Ardigo, Marco ;

Tosti, Antonella ;

Cameli, Norma ;

Vincenzi, Colombina ;

Misciali, Cosimo ;

Berardesca, Enzo .

ARCHIVES OF DERMATOLOGY, 2011, 147 (01) :61-64

[3] Major histocompatibility complex class I chain-related gene A polymorphisms and extended haplotypes are associated with familial alopecia areata [J].

Barahmani, Nazila ;

de Andrade, Mariza ;

Slusser, Joshua P. ;

Zhang, Qing ;

Duvic, Madeleine .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 (01) :74-78

[4] CTLA4 exon1 A49G polymorphism in Slovak patients with rheumatoid arthritis and Hashimoto thyroiditis-results and the review of the literature [J].

Benhatchi, Karim ;

Jochmanova, Ivana ;

Habalova, Viera ;

Wagnerova, Hedviga ;

Lazurova, Ivica .

CLINICAL RHEUMATOLOGY, 2011, 30 (10) :1319-1324

[5] Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci [J].

Betz, Regina C. ;

Petukhova, Lynn ;

Ripke, Stephan ;

Huang, Hailiang ;

Menelaou, Androniki ;

Redler, Silke ;

Becker, Tim ;

Heilmann, Stefanie ;

Yamany, Tarek ;

Duvic, Madeliene ;

Hordinsky, Maria ;

Norris, David ;

Price, Vera H. ;

Mackay-Wiggan, Julian ;

de Jong, Annemieke ;

DeStefano, Gina M. ;

Moebus, Susanne ;

Boehm, Markus ;

Blume-Peytavi, Ulrike ;

Wolff, Hans ;

Lutz, Gerhard ;

Kruse, Roland ;

Bian, Li ;

Amos, Christopher I. ;

Lee, Annette ;

Gregersen, Peter K. ;

Blaumeiser, Bettina ;

Altshuler, David ;

Clynes, Raphael ;

de Bakker, Paul I. W. ;

Noethen, Markus M. ;

Daly, Mark J. ;

Christiano, Angela M. .

NATURE COMMUNICATIONS, 2015, 6

[6] Safety and Efficacy of Adalimumab for the Treatment of Severe Alopecia Areata: Case Series of Three Patients [J].

Bolduc, Chantal ;

Bissonnette, Robert .

JOURNAL OF CUTANEOUS MEDICINE AND SURGERY, 2012, 16 (04) :257-260

[7] Effects of Low-Dose Recombinant Interleukin 2 to Promote T-Regulatory Cells in Alopecia Areata [J].

Castela, Emeline ;

Le Duff, Florence ;

Butori, Catherine ;

Ticchioni, Michel ;

Hofman, Paul ;

Bahadoran, Philippe ;

Lacour, Jean-Philippe ;

Passeron, Thierry .

JAMA DERMATOLOGY, 2014, 150 (07) :748-751

[8]

COLOMBE BW, 1995, J AM ACAD DERMATOL, V33, P757

[9] Safety and efficacy of the JAK inhibitor tofacitinib citrate in patients with alopecia areata [J].

Crispin, Milene Kennedy ;

Ko, Justin M. ;

Craiglow, Brittany G. ;

Li, Shufeng ;

Shankar, Gautam ;

Urban, Jennifer R. ;

Chen, James C. ;

Cerise, Jane E. ;

Jabbari, Ali ;

Winge, Marten C. G. ;

Marinkovich, M. Peter ;

Christiano, Angela M. ;

Oro, Anthony E. ;

King, Brett A. .

JCI INSIGHT, 2016, 1 (15)

[10] CXCR3 Blockade Inhibits T Cell Migration into the Skin and Prevents Development of Alopecia Areata [J].

Dai, Zhenpeng ;

Xing, Luzhou ;

Cerise, Jane ;

Wang, Eddy Hsi Chun ;

Jabbari, Ali ;

de Jong, Annemieke ;

Petukhova, Lynn ;

Christiano, Angela M. ;

Clynes, Raphael .

JOURNAL OF IMMUNOLOGY, 2016, 197 (04) :1089-1099

← 1 2 3 4 5 →