Effect of COVID-19 on Anti-S Antibody Response in Healthcare Workers Six Months Post-Vaccination

被引:8
作者
Flisiak, Robert [1 ]
Pawlowska, Malgorzata [2 ]
Rogalska-Plonska, Magdalena [1 ]
Bociaga-Jasik, Monika [3 ]
Klos, Krzysztof [4 ]
Piekarska, Anna [5 ]
Zarebska-Michaluk, Dorota [6 ]
机构
[1] Med Univ Bialystok, Dept Infect Dis & Hepatol, PL-15540 Balystok, Poland
[2] Nicolaus Copernicus Univ, Coll Med Bydgoszcz, Fac Med, Dept Infect Dis & Hepatol, PL-85067 Bydgoszcz, Poland
[3] Jagiellonian Univ, Med Coll, Dept Infect & Trop Dis, PL-31007 Krakow, Poland
[4] Mil Inst Med, Dept Infect Dis & Allergol, PL-04141 Warsaw, Poland
[5] Med Univ Lodz, Dept Infect Dis & Hepatol, PL-90419 Lodz, Poland
[6] Jan Kochanowski Univ, Dept Infect Dis, PL-25317 Kielce, Poland
关键词
COVID-19; SARS-CoV-2; vaccination;
D O I
10.3390/vaccines9111325
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The current study aimed to determine to what extent prior COVID-19 infection affects the response of specific antibodies following vaccination. The study involved 173 healthcare professionals who completed the two-dose vaccination course with BNT162b2, including 40 who previously experienced clinical COVID-19. The levels of anti-SARS-CoV-2 S1S2 IgG (anti-S) and, in some cases, anti-SARS-CoV-S-RBD IgG (anti-S-RBD) were determined six months after complete vaccination. A level exceeding the cut-off values for both anti-S and anti-S-RBD was observed in 100% of subjects, but after setting the analysis to 5- and 10-fold cut-off levels, the percentage of subjects meeting this criterion was significantly higher for anti-S-RBD. The 100-fold cut-off level was achieved by only 21% and 16% for anti-S and anti-S-RBD, respectively. Anti-S and anti-S-RBD levels above ten times the positive cut-off were respectively observed in 91% and 100% individuals with a history of COVID-19, while among those without COVID-19, these values were 64% and 90%, respectively. Significantly higher incidence of values above 10 and 100 times the cut-off became apparent among people with a history of COVID-19. In conclusion, vaccination against COVID-19 following infection with the disease provides higher levels of specific antibodies 6 months after vaccination than those of individuals without a history of the disease, which supports the use of a booster dose, particularly for those who have not experienced SARS-CoV-2 infection.
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页数:5
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