Long-lived state in a four-spin system hyperpolarized at room temperature

A solution with hyperpolarized nuclear spins encoded into a long-lived state has been utilized for sensing chemical phenomena. In a conventional way, nuclear spins are hyperpolarized at very low temperatures. In this work, we demonstrate the encoding of a four-nuclear-spin system hyperpolarized at room temperature into a long-lived state in a solution. We apply the solution with the long-lived state as a sensor in ligand-receptor binding experiments.