Evidence for the combined participation of a C10 and a C15 precursor in the biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics

被引：11
作者：
Neundorf, I
Köhler, C
Hennig, L
Findeisen, M
Arigoni, D
Welzel, P
机构：
[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland
[2] Univ Leipzig, Fak Chem & Mineral, D-04103 Leipzig, Germany
来源：
CHEMBIOCHEM | 2003年 / 4卷 / 11期
关键词：
D O I：
10.1002/cbic.200300622
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Upon feeding of [2-C-13,4-2H]-1-deoxy-D-xylulose to <LF>Streptomyces ghanaensis, the deuterium label was retained exclusively at positions C-7 and C-17 in the moenocinol part of the moenomycin antibiotics. This result vindicates the hypothesis that the C-25 structure of moenocinol is assembled from a C-10 and a C-15 precursor each of which requires for its formation the involvement of a dimethylallyl diphosphate starter unit.
引用
收藏
页码：1201 / 1205
页数：5
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