Derivation of a prototype asthma attack risk scale centred on blood eosinophils and exhaled nitric oxide

被引：98

作者：

Couillard, Simon ^{[1
,2
]}

Laugerud, Annette ^{[3
]}

Jabeen, Maisha ^{[1
]}

Ramakrishnan, Sanjay ^{[1
,4
]}

Melhorn, James ^{[1
]}

Hinks, Timothy ^{[1
]}

Pavord, Ian ^{[1
]}

机构：

[1] Univ Oxford, Nuffield Dept Med, Resp Med Unit, Oxford OX3 7FZ, Oxon, England

[2] Univ Sherbrooke, Fac Med & Sci Sante, Sherbrooke, PQ, Canada

[3] Sanofi Genzyme Norway, Div Immunol, Oslo, Norway

[4] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia

来源：

THORAX | 2022年 / 77卷 / 02期

基金：

英国惠康基金;

关键词：

asthma; exhaled airway markers; eosinophil biology; asthma epidemiology; respiratory measurement; pulmonary eosinophilia; clinical epidemiology; allergic lung disease;

D O I：

10.1136/thoraxjnl-2021-217325

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Reduction of the risk of asthma attacks is a major goal of current asthma management. We propose to derive a risk scale predicting asthma attacks based on the blood eosinophil count and exhaled nitric oxide (FeNO). Biomarker-stratified trial-level attack rates were extracted and pooled from the control arms of the Novel START, CAPTAIN, QUEST, Benralizumab Phase 2b, PATHWAY, STRATOS 1-2 and DREAM trials (n=3051). These were used to derive rate ratios and the predicted asthma attack rate for different patient groups. The resultant prototype risk scale shows potential to predict asthma attacks, which may be prevented by anti-inflammatory treatment.

引用

页码：199 / 202

页数：4

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