The role of fibroblast growth factor 21 in diabetes and its complications: A review from clinical perspective

被引：47

作者：

Liu, Jian-Jun ^{[1
]}

Foo, Joo Pin ^{[2
]}

Liu, Sylvia ^{[1
]}

Lim, Su Chi ^{[3
]}

机构：

[1] Khoo Teck Puat Hosp, Clin Res Unit, Singapore 768828, Singapore

[2] Changi Gen Hosp, Dept Med, Singapore, Singapore

[3] Khoo Teck Puat Hosp, Ctr Diabet, Singapore 768828, Singapore

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2015年 / 108卷 / 03期

关键词：

Fibroblast growth factor 21; Diabetes; Diabetes complications; Diabetes therapy; INCREASES ENERGY-EXPENDITURE; FATTY LIVER-DISEASE; SERUM FGF21 LEVELS; INSULIN SENSITIVITY; METABOLIC SYNDROME; GLUCOSE; OBESITY; EXPRESSION; RESISTANCE; INHIBITION;

D O I：

10.1016/j.diabres.2015.02.032

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fibroblast growth factor 21 (FGF21) has been well-recognized as a metabolic hormone and a promising target for treatment of metabolic diseases. The level of endogenous FGF21 is elevated in patients with impaired glucose tolerance and progressively increased from patients with overt type 2 diabetes to those with micro-and macro-vascular complications, presumably as a compensation or response to the deterioration of metabolic imbalance. A few exploratory in vivo studies, including a recent clinical trial, showed that exogenous FGF21 mimetics targeting FGF21 signaling can attain beneficial metabolic effects not withstanding the already elevated ambient FGF21 levels. In addition, some clinically available pharmacologic agents such as fenofibrates and metformin may modulate energy and macronutrients metabolism by acting through FGF21. This review mainly focuses on the role of FGF21 in development, progression and treatment of type 2 diabetes from a clinical perspective. (c) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：382 / 389

页数：8

共 66 条

[31] Lemons for Obesity [J].

Lauer, Michael S. .

ANNALS OF INTERNAL MEDICINE, 2012, 157 (02) :139-+

[32] Fibroblast growth factor 21 (FGF21) and bone: is there a relationship in humans? [J].

Lee, P. ;

Linderman, J. ;

Smith, S. ;

Brychta, R. J. ;

Perron, R. ;

Idelson, C. ;

Werner, C. D. ;

Chen, K. Y. ;

Celi, F. S. .

OSTEOPOROSIS INTERNATIONAL, 2013, 24 (12) :3053-3057

[33] Serum fibroblast growth factor 21 is predictive of combined cardiovascular morbidity and mortality in patients with type 2 diabetes at a relatively short-term follow-up [J].

Lenart-Lipinska, M. ;

Matyjaszek-Matuszek, B. ;

Gernand, W. ;

Nowakowski, A. ;

Solski, J. .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2013, 101 (02) :194-200

[34] Serum FGF21 levels are increased in newly diagnosed type 2 diabetes with nonalcoholic fatty liver disease and associated with hsCRP levels independently [J].

Li, Xuesong ;

Fan, Xiaofang ;

Ren, Fengdong ;

Zhang, Yu ;

Shen, Chunfang ;

Ren, Guoguang ;

Sun, Jue ;

Zhang, Ning ;

Wang, Weiqing ;

Ning, Guang ;

Yang, Jialin .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2011, 93 (01) :10-16

[35] Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice [J].

Lin, Zhuofeng ;

Tian, Haishan ;

Lam, Karen S. L. ;

Lin, Shaoqiang ;

Hoo, Ruby C. L. ;

Konishi, Morichika ;

Itoh, Nobuyuki ;

Wang, Yu ;

Bornstein, Stefan R. ;

Xu, Aimin ;

Li, Xiaokun .

CELL METABOLISM, 2013, 17 (05) :779-789

[36] Circulating FGF21 Levels Are Progressively Increased from the Early to End Stages of Chronic Kidney Diseases and Are Associated with Renal Function in Chinese [J].

Lin, Zhuofeng ;

Zhou, Zhihong ;

Liu, Yanlong ;

Gong, Qi ;

Yan, Xinxin ;

Xiao, Jian ;

Wang, Xiaojie ;

Lin, Shaoqiang ;

Feng, Wenke ;

Li, Xiaokun .

PLOS ONE, 2011, 6 (04)

[37] Type VIII Collagen Modulates TGF-β1-induced Proliferation of Mesangial Cells [J].

Loeffler, Ivonne ;

Hopfer, Ulrike ;

Koczan, Dirk ;

Wolf, Gunter .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (04) :649-663

[38] Physiological modulation of circulating FGF21: relevance of free fatty acids and insulin [J].

Mai, Knut ;

Bobbert, Thomas ;

Groth, Christian ;

Assmann, Anke ;

Meinus, Sabine ;

Kraatz, Jessica ;

Andres, Janin ;

Arafat, Ayman M. ;

Pfeiffer, Andreas F. H. ;

Moehlig, Matthias ;

Spranger, Joachim .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2010, 299 (01) :E126-E130

[39] Free Fatty Acids Link Metabolism and Regulation of the Insulin-Sensitizing Fibroblast Growth Factor-21 [J].

Mai, Knut ;

Andres, Janin ;

Biedasek, Katrin ;

Weicht, Jessica ;

Bobbert, Thomas ;

Sabath, Markus ;

Meinus, Sabine ;

Reinecke, Franziska ;

Moehlig, Matthias ;

Weickert, Martin O. ;

Clemenz, Markus ;

Pfeiffer, Andreas F. H. ;

Kintscher, Ulrich ;

Spuler, Simone ;

Spranger, Joachim .

DIABETES, 2009, 58 (07) :1532-1538

[40] Diabetes group warns vascular complication is underdiagnosed and undertreated [J].

Mitka, M .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (07) :809-810

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