Phytochemicals for the treatment of COVID-19

被引：18
作者：
Espano, Erica [1 ]
Kim, Jiyeon [1 ]
Lee, Kiho [1 ]
Kim, Jeong-Ki [1 ]
机构：
[1] Korea Univ, Coll Pharm, Dept Pharm, Sejong 30019, South Korea
来源：
JOURNAL OF MICROBIOLOGY | 2021年 / 59卷 / 11期
关键词：
antivirals; alkaloids; coronaviruses; COVID-19; flavonoids; phytochemicals; natural products; SARS-CoV-2; SARS-COV-2; PROTEASE; INHIBIT; ANDROGRAPHOLIDE; REPLICATION; EXTRACT; TMPRSS2;
D O I：
10.1007/s12275-021-1467-z
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The coronavirus disease 2019 (COVID-19) pandemic has underscored the lack of approved drugs against acute viral diseases. Plants are considered inexhaustible sources of drugs for several diseases and clinical conditions, but plant-derived compounds have seen little success in the field of antivirals. Here, we present the case for the use of compounds from vascular plants, including alkaloids, flavonoids, polyphenols, and tannins, as antivirals, particularly for the treatment of COVID-19. We review current evidence for the use of these phytochemicals against SARS-CoV-2 infection and present their potential targets in the SARS-CoV-2 replication cycle.
引用
收藏
页码：959 / 977
页数：19
相关论文
共 79 条
  • [51] In vitro evaluation of antiviral activity of single and combined repurposable drugs against SARS-CoV-2
    Pizzorno, Andres
    Padey, Blandine
    Dubois, Julia
    Julien, Thomas
    Traversier, Aurelien
    Duliere, Victoria
    Brun, Pauline
    Lina, Bruno
    Rosa-Calatrava, Manuel
    Terrier, Olivier
    [J]. ANTIVIRAL RESEARCH, 2020, 181
  • [52] Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications
    Rahman, Heshu Sulaiman
    Othman, Hemn Hassan
    Hammadi, Nahidah Ibrahim
    Yeap, Swee Keong
    Amin, Kawa Mohammad
    Samad, Nozlena Abdul
    Alitheen, Noorjahan Banu
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 15 : 2439 - 2483
  • [53] Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives
    Sa-ngiamsuntorn, Khanit
    Suksatu, Ampa
    Pewkliang, Yongyut
    Thongsri, Piyanoot
    Kanjanasirirat, Phongthon
    Manopwisedjaroen, Suwimon
    Charoensutthivarakul, Sitthivut
    Wongtrakoongate, Patompon
    Pitiporn, Supaporn
    Chaopreecha, Jarinya
    Kongsomros, Supasek
    Jearawuttanakul, Kedchin
    Wannalo, Warawuth
    Khemawoot, Phisit
    Chutipongtanate, Somchai
    Borwornpinyo, Suparerk
    Thitithanyanont, Arunee
    Hongeng, Suradej
    [J]. JOURNAL OF NATURAL PRODUCTS, 2021, 84 (04): : 1261 - 1270
  • [54] Quinacrine, an Antimalarial Drug with Strong Activity Inhibiting SARS-CoV-2 Viral Replication In Vitro
    Salas Rojas, Monica
    Silva Garcia, Raul
    Bini, Estela
    Perez de la Cruz, Veronica
    Leon Contreras, Juan Carlos
    Hernandez Pando, Rogelio
    Bastida Gonzalez, Fernando
    Davila-Gonzalez, Eduardo
    Orozco Morales, Mario
    Gamboa Dominguez, Armando
    Sotelo, Julio
    Pineda, Benjamin
    [J]. VIRUSES-BASEL, 2021, 13 (01):
  • [55] Santos E.L., 2017, INTECHOPEN, DOI [10.5772/67861, DOI 10.5772/67861]
  • [56] Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage
    Shi, Tzu-Hau
    Huang, Yi-Long
    Chen, Chiao-Che
    Pi, Wen-Chieh
    Hsu, Yu-Ling
    Lo, Lee-Chiang
    Chen, Wei-Yi
    Fu, Shu-Ling
    Lin, Chao-Hsiung
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 533 (03) : 467 - 473
  • [57] The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro
    Song, Junke
    Zhang, Li
    Xu, Yanfeng
    Yang, Dezhi
    Zhang, Li
    Yang, Shiying
    Zhang, Wen
    Wang, Jinhua
    Tian, Shuo
    Yang, Shengqian
    Yuan, Tianyi
    Liu, Ailin
    Lv, Qi
    Li, Fengdi
    Liu, Hongqi
    Hou, Biyu
    Peng, Xiaozhong
    Lu, Yang
    Du, Guanhua
    [J]. BIOCHEMICAL PHARMACOLOGY, 2021, 183
  • [58] Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2
    Stefanik, Michal
    Strakova, Petra
    Haviernik, Jan
    Miller, Andrew D.
    Ruzek, Daniel
    Eyer, Ludek
    [J]. MICROORGANISMS, 2021, 9 (03) : 1 - 10
  • [59] Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients
    Su, Hai-xia
    Yao, Sheng
    Zhao, Wen-feng
    Li, Min-jun
    Liu, Jia
    Shang, Wei-juan
    Xie, Hang
    Ke, Chang-qiang
    Hu, Hang-chen
    Gao, Mei-na
    Yu, Kun-qian
    Liu, Hong
    Shen, Jing-shan
    Tang, Wei
    Zhang, Lei-ke
    Xiao, Geng-fu
    Ni, Li
    Wang, Dao-wen
    Zuo, Jian-ping
    Jiang, Hua-liang
    Bai, Fang
    Wu, Yan
    Ye, Yang
    Xu, Ye-chun
    [J]. ACTA PHARMACOLOGICA SINICA, 2020, 41 (09) : 1167 - 1177
  • [60] Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air-Liquid Interface Cultured Human Primary Bronchial Epithelial Cells
    ter Ellen, Bram M.
    Kumar, Nilima Dinesh
    Bouma, Ellen M.
    Troost, Berit
    van de Pol, Denise P., I
    Van der Ende-Metselaar, Heidi H.
    Apperloo, Leonie
    van Gosliga, Djoke
    van den Berge, Maarten
    Nawijn, Martijn C.
    van der Voort, Peter H. J.
    Moser, Jill
    Rodenhuis-Zybert, Izabela A.
    Smit, Jolanda M.
    [J]. VIRUSES-BASEL, 2021, 13 (07):
12345678