Periodontal cell mechanotransduction

被引：38

作者：

Chukkapalli, Sasanka S. ^{[1
,2
]}

Lele, Tanmay P. ^{[3
]}

机构：

[1] Univ Florida, Coll Dent, Dept Oral Biol, Gainesville, FL 32610 USA

[2] Univ Florida, Coll Dent, Ctr Mol Microbiol, Gainesville, FL 32610 USA

[3] Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA

来源：

OPEN BIOLOGY | 2018年 / 8卷 / 09期

基金：

美国国家卫生研究院;

关键词：

mechanobiology; mechanotransduction; cytoskeleton; periodontal disease; cell shape; traction force; MUCOPERIOSTEAL FLAP SURGERY; ALVEOLAR BONE-RESORPTION; INDUCED OSTEOGENIC DIFFERENTIATION; MESSENGER-RNA EXPRESSION; DEPENDENT UP-REGULATION; LIGAMENT CELLS; MECHANICAL-STRESS; EXTRACELLULAR-MATRIX; GENE-EXPRESSION; GINGIVAL FIBROBLASTS;

D O I：

10.1098/rsob.180053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The periodontium is a structurally and functionally complex tissue that facilitates the anchorage of teeth in jaws. The periodontium consists of various cell types including stem cells, fibroblasts and epithelial cells. Cells of the periodontium are constantly exposed to mechanical stresses generated by biological processes such as the chewing motions of teeth, by flows generated by tongue motions and by forces generated by implants. Mechanical stresses modulate the function of cells in the periodontium, and may play a significant role in the development of periodontal disease. Here, we review the literature on the effect of mechanical forces on periodontal cells in health and disease with an emphasis on molecular and cellular mechanisms.

引用

页数：7

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