Thiazole and Oxazole Alkaloids: Isolation and Synthesis

被引：177

作者：

Davyt, Danilo ^{[1
]}

Serra, Gloria ^{[1
]}

机构：

[1] UdelaR, Fac Quim, Catedra Quim Farmaceut, Montevideo, Uruguay

来源：

MARINE DRUGS | 2010年 / 8卷 / 11期

关键词：

thiazole; oxazole; marine; ENANTIOSELECTIVE TOTAL-SYNTHESIS; CONCISE TOTAL-SYNTHESIS; BIOLOGICAL EVALUATION; STEREOCHEMICAL REASSIGNMENT; STRUCTURE REVISION; LARGAZOLE ANALOGS; SPONGE; NEOPELTOLIDE; MACROLIDE; PEPTIDES;

D O I：

10.3390/md8112755

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thiazoles, oxazole and their corresponding reduced derivatives, thiazolines and oxazolines, are found in marine sources exhibiting significant biological activities. The isolation, synthetic, and biological studies of these natural products, covering literature from January 2007 to June 2010, are summarized.

引用

页码：2755 / 2780

页数：26

共 87 条

[1] Valence Tautomerism in Titanium Enolates: Catalytic Radical Haloalkylation and Application in the Total Synthesis of Neodysidenin [J].

Beaumont, Stephane ;

Ilardi, Elizabeth A. ;

Monroe, Lucas R. ;

Zakarian, Armen .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (05) :1482-+

[2] Taumycins A and B, two bioactive lipodepsipeptides from the Madagascar sponge Fascaplysinopsis sp. [J].

Bishara, Ashgan ;

Rudi, Amira ;

Aknin, Maurice ;

Neumann, Drorit ;

Ben-Califa, Nathalie ;

Kashman, Yoel .

ORGANIC LETTERS, 2008, 10 (19) :4307-4309

[3] Salarin C, a new cytotoxic sponge-derived nitrogenous macrolide [J].

Bishara, Ashgan ;

Rudi, Amira ;

Aknin, Maurice ;

Neumann, Drorit ;

Ben-Califa, Nathalie ;

Kashman, Yoel .

TETRAHEDRON LETTERS, 2008, 49 (28) :4355-4358

[4] Salarins D-J, seven new nitrogenous macrolides from the madagascar sponge Fascaplysinopsis sp. [J].

Bishara, Ashgan ;

Rudi, Amira ;

Aknin, Maurice ;

Neumann, Drorit ;

Ben-Califa, Nathalie ;

Kashman, Yoel .

TETRAHEDRON, 2010, 66 (24) :4339-4345

[5] Total synthesis and biological mode of action of largazole: A potent Class I histone deacetylase inhibitor [J].

Bowers, Albert ;

West, Nathan ;

Taunton, Jack ;

Schreiber, Stuart L. ;

Bradner, James E. ;

Williams, Robert M. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (33) :11219-11222

[6] Synthesis and Conformation-Activity Relationships of the Peptide Isosteres of FK228 and Largazole [J].

Bowers, Albert A. ;

Greshock, Thomas J. ;

West, Nathan ;

Estiu, Guillermina ;

Schreiber, Stuart L. ;

Wiest, Olaf ;

Williams, Robert M. ;

Bradner, James E. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (08) :2900-2905

[7] Synthesis and Histone Deacetylase Inhibitory Activity of Largazole Analogs: Alteration of the Zinc-Binding Domain and Macrocyclic Scaffold [J].

Bowers, Albert A. ;

West, Nathan ;

Newkirk, Tenaya L. ;

Troutman-Youngman, Annie E. ;

Schreiber, Stuart L. ;

Wiest, Olaf ;

Bradner, James E. ;

Williams, Robert M. .

ORGANIC LETTERS, 2009, 11 (06) :1301-1304

[8] Total synthesis of potent antifungal marine bisoxazole natural products bengazoles A and B [J].

Bull, James A. ;

Balskus, Emily P. ;

Horan, Richard A. J. ;

Langner, Martin ;

Ley, Steven V. .

CHEMISTRY-A EUROPEAN JOURNAL, 2007, 13 (19) :5515-5538

[9] Patellins 1-6 and trunkamide A: Novel cyclic hexa-, hepta- and octa-peptides from colonial ascidians, Lissoclinum sp [J].

Carroll, AR ;

Coll, JC ;

Bourne, DJ ;

MacLeod, JK ;

Zabriskie, TM ;

Ireland, CM ;

Bowden, BF .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1996, 49 (06) :659-667

[10] Total Synthesis of Bengazole A [J].

Chandrasekhar, Srivari ;

Sudhakar, Ambadi .

ORGANIC LETTERS, 2010, 12 (02) :236-238

← 1 2 3 4 5 6 7 8 9 →