Antioxidative and cytotoxic activity of essential oils and extracts of Satureja montana L., Conundrum sativum L. and Ocimum basilicum L. obtained by supercritical fluid extraction

被引：71

作者：

Elgndi, Mohamed Ahmed ^{[1
]}

Filip, Snezana ^{[1
]}

Pavlic, Branimir ^{[1
]}

Vladic, Jelena ^{[1
]}

Stanojkovic, Tatjana ^{[2
]}

Zizak, Zeljko ^{[2
]}

Zekovic, Zoran ^{[1
]}

机构：

[1] Univ Novi Sad, Fac Technol, Bulevar Cara Lazara 1, Novi Sad 21000, Serbia

[2] Inst Oncol & Radiol Serbia, Pasterova 14, Belgrade 11000, Serbia

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2017年 / 128卷

关键词：

Medicinal plants; Supercritical fluid extraction; Essential oil; Chemical profile; Antioxidant and antiproliferative activity; CARBON-DIOXIDE EXTRACTION; CHEMICAL-COMPOSITION; CORIANDRUM-SATIVUM; ANTIMICROBIAL ACTIVITY; VOLATILE OIL; LUNG-CANCER; FRACTIONS; THAILAND; PLANTS; HERBS;

D O I：

10.1016/j.supflu.2017.05.025

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this study, lipid extracts obtained by supercritical fluid extraction and essential oils of Satureja montana L., Coriandrum sativum L. and Ocimum basilicum L., as well as the mixture of these aromatic herbs were investigated. Obtained extracts and essential oils were analyzed by GC MS and GC-FID. The chemical profile of obtained EOs and extracts showed that carvacrol was the major compound in S. montana, while in C. sativum and O. basilicum linalool was the most abundant compound. In the EO obtained from herbal mixture of three aromatic plants, the predominant compounds were linalool and carvacrol, followed by geraniol, gamma-terpinene and eugenol, similar with extract obtained by SFE (100 bar, 40 degrees C). The antioxidant activity was determined by DPPH assay, while antiproliferative activity of the obtained CO2 extracts and the essential oils were evaluated in vitro against three different human cancer cell lines (HeLa, MDA-MB-453, K562) and normal MRC-5 human fibroblasts.

引用

页码：128 / 137

页数：10

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