Asymmetric alkylation of remote C(sp3)-H bonds by combining proton-coupled electron transfer with chiral Lewis acid catalysis

被引：100
|
作者：
Yuan, Wei [1 ]
Zhou, Zijun [1 ]
Gong, Lei [1 ]
Meggers, Eric [1 ,2 ]
机构：
[1] Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China
[2] Philipps Univ Marburg, Fachbereich Chem, Hans Meerwein Str 4, D-35043 Marburg, Germany
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 64期
基金：
中国国家自然科学基金;
关键词：
C-H BONDS; PHOTOREDOX CATALYSIS; ACTIVATION; FUNCTIONALIZATION; RADICALS; AMINATION; STRATEGY; COMPLEX; IODINE;
D O I：
10.1039/c7cc04941b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The catalytic asymmetric alkylation of the remote, unactivated delta-position of N-alkyl amides was enabled by the combination of visible-light-induced proton-coupled electron transfer, 1,5-hydrogen atomtransfer, and chiral Lewis acid catalysis in up to 82% yield and up to 97% ee.
引用
收藏
页码：8964 / 8967
页数：4
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