DNA Methylation: A Target in Neuropathic Pain

被引：10

作者：

Jiang, Wei ^{[1
,2
]}

Tan, Xuan-Yu ^{[3
]}

Li, Jia-Ming ^{[4
]}

Yu, Peng ^{[5
]}

Dong, Ming ^{[1
,2
]}

机构：

[1] First Hosp Jilin Univ, Dept Neurol, Changchun, Peoples R China

[2] First Hosp Jilin Univ, Neurosci Ctr, Changchun, Peoples R China

[3] First Hosp Jilin Univ, Dept Neurosurg, Changchun, Peoples R China

[4] First Hosp Jilin Univ, Dept Emergency, Changchun, Peoples R China

[5] Second Hosp Jilin Univ, Dept Ophthalmol, Changchun, Peoples R China

来源：

FRONTIERS IN MEDICINE | 2022年 / 9卷

基金：

中国国家自然科学基金;

关键词：

neuropathic pain; DNA methylation; gene suppression; epigenetic; treatment; DORSAL-ROOT GANGLION; CPG-BINDING PROTEIN-2; MAMMALIAN DNA; METHYLTRANSFERASE INHIBITORS; OPIOID RECEPTOR; DOWN-REGULATION; SEX-DIFFERENCES; TET PROTEINS; EXPRESSION; EPIGENETICS;

D O I：

10.3389/fmed.2022.879902

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Neuropathic pain (NP), caused by an injury or a disease affecting the somatosensory nervous system of the central and peripheral nervous systems, has become a global health concern. Recent studies have demonstrated that epigenetic mechanisms are among those that underlie NP; thus, elucidating the molecular mechanism of DNA methylation is crucial to discovering new therapeutic methods for NP. In this review, we first briefly discuss DNA methylation, demethylation, and the associated key enzymes, such as methylases and demethylases. We then discuss the relationship between NP and DNA methylation, focusing on DNA methyltransferases including methyl-CpG-binding domain (MBD) family proteins and ten-eleven translocation (TET) enzymes. Based on experimental results of neuralgia in animal models, the mechanism of DNA methylation-related neuralgia is summarized, and useful targets for early drug intervention in NP are discussed.

引用

页数：10

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