ATP TRAPPING AT NBD1 INFLUENCES CFTR STABILITY AND FUNCTION

被引：0

作者：

Aleksandrov, Luba A. ^{[1
]}

Cui, Liying ^{[1
]}

He, Lihua ^{[1
]}

Aleksandrov, Andrei A. ^{[1
]}

Riordan, John R. ^{[1
]}

机构：

[1] UNC Sch Med, Dept Biochem & Biophys, Chapel Hill, NC USA

来源：

PEDIATRIC PULMONOLOGY | 2010年

关键词：

NUCLEOTIDE-BINDING DOMAIN; CYSTIC-FIBROSIS; CHANNEL; 2ND;

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

引用

页码：113 / 114

页数：2

共 7 条

[1]

Aleksandrov AA, J MOL BIOL

[2] The first nucleotide binding domain of cystic fibrosis transmembrane conductance regulator is a site of stable nucleotide interaction, whereas the second is a site of rapid turnover [J].

Aleksandrov, L ;

Aleksandrov, AA ;

Chang, XB ;

Riordan, JR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (18) :15419-15425

[3] Mg2+-dependent ATP occlusion at the first nucleotide-binding domain (NBD1) of CFTR does not require the second (NBD2) [J].

Aleksandrov, Luba ;

Aleksandrov, Andrei ;

Riordan, John R. .

BIOCHEMICAL JOURNAL, 2008, 416 :129-136

[4] CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices [J].

Baker, Jennifer M. R. ;

Hudson, Rhea P. ;

Kanelis, Voula ;

Choy, Wing-Yiu ;

Thibodeau, Patrick H. ;

Thomas, Philip J. ;

Forman-Kay, Julie D. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (08) :738-745

[5] Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating [J].

Basso, C ;

Vergani, P ;

Nairn, AC ;

Gadsby, DC .

JOURNAL OF GENERAL PHYSIOLOGY, 2003, 122 (03) :333-348

[6] The ABC protein turned chloride channel whose failure causes cystic fibrosis [J].

Gadsby, DC ;

Vergani, P ;

Csanády, L .

NATURE, 2006, 440 (7083) :477-483

[7] Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function [J].

Serohijos, Adrian W. R. ;

Hegedus, Tamas ;

Aleksandrov, Andrei A. ;

He, Lihua ;

Cui, Liying ;

Dokholyan, Nikolay V. ;

Riordan, John R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (09) :3256-3261

← 1 →