More Is Less: IL-9 in the Resolution of Inflammation

被引：11
作者：
Karagiannis, Fotios [1 ]
Wilhelm, Christoph [1 ]
机构：
[1] Univ Bonn, Univ Hosp Bonn, Dept Clin Chem & Clin Pharmacol, Unit Immunopathol, D-53127 Bonn, Germany
来源：
IMMUNITY | 2017年 / 47卷 / 03期
关键词：
INNATE LYMPHOID-CELLS; LUNG INFLAMMATION; SURVIVAL;
D O I：
10.1016/j.immuni.2017.09.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In a recent study in Nature Medicine, Rauber et al. (2017) identify interleukin-9 (IL-9) derived from group 2 innate lymphoid cells as crucial regulators inducing resolution of chronic inflammation in rheumatoid arthritis. Their findings provide insight into the varied functions of IL-9 and open the door to novel therapeutic interventions.
引用
收藏
页码：403 / 405
页数：3
相关论文
共 10 条
[1]   IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells [J].
Elyaman, Wassim ;
Bradshaw, Elizabeth M. ;
Uyttenhove, Catherine ;
Dardalhon, Valerie ;
Awasthi, Amit ;
Imitola, Jaime ;
Bettelli, Estelle ;
Oukka, Mohamed ;
van Snick, Jacques ;
Renauld, Jean-Christophe ;
Kuchroo, Vijay K. ;
Khoury, Samia J. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (31) :12885-12890
[2]   TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells [J].
Gerlach, Katharina ;
Hwang, YouYi ;
Nikolaev, Alexej ;
Atreya, Raja ;
Dornhoff, Heike ;
Steiner, Stefanie ;
Lehr, Hans-Anton ;
Wirtz, Stefan ;
Vieth, Michael ;
Waisinan, Ari ;
Rosenbauer, Frank ;
McKenzie, Andrew N. J. ;
Weigmann, Benno ;
Neurath, Markus F. .
NATURE IMMUNOLOGY, 2014, 15 (07) :676-686
[3]   A Brief History of IL-9 [J].
Goswami, Ritobrata ;
Kaplan, Mark H. .
JOURNAL OF IMMUNOLOGY, 2011, 186 (06) :3283-3288
[4]   Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis [J].
Mohapatra, A. ;
Van Dyken, S. J. ;
Schneider, C. ;
Nussbaum, J. C. ;
Liang, H-E ;
Locksley, R. M. .
MUCOSAL IMMUNOLOGY, 2016, 9 (01) :275-286
[5]   IL-9 as a mediator of Th17-driven inflammatory disease [J].
Nowak, Elizabeth C. ;
Weaver, Casey T. ;
Turner, Henrietta ;
Begum-Haque, Sakhina ;
Becher, Burkhard ;
Schreiner, Bettina ;
Coyle, Anthony J. ;
Kasper, Lloyd H. ;
Noelle, Randolph J. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (08) :1653-1660
[6]   Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells [J].
Rauber, Simon ;
Luber, Markus ;
Weber, Stefanie ;
Maul, Lisa ;
Soare, Alina ;
Wohlfahrt, Thomas ;
Lin, Neng-Yu ;
Dietel, Katharina ;
Bozec, Aline ;
Herrmann, Martin ;
Kaplan, Mark H. ;
Weigmann, Benno ;
Zaiss, Mario M. ;
Fearon, Ursula ;
Veale, Douglas J. ;
Canete, Juan D. ;
Distler, Oliver ;
Rivellese, Felice ;
Pitzalis, Costantino ;
Neurath, Markus F. ;
McKenzie, Andrew N. J. ;
Wirtz, Stefan ;
Schett, Georg ;
Distler, Joerg H. W. ;
Ramming, Andreas .
NATURE MEDICINE, 2017, 23 (08) :938-+
[7]   Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators [J].
Serhan, Charles N. ;
Chiang, Nan ;
Van Dyke, Thomas E. .
NATURE REVIEWS IMMUNOLOGY, 2008, 8 (05) :349-361
[8]   IL-9-mediated survival of type 2 innate lymphoid cells promotes damage control in helminth-induced lung inflammation [J].
Turner, Jan-Eric ;
Morrison, Peter J. ;
Wilhelm, Christoph ;
Wilson, Mark ;
Ahlfors, Helena ;
Renauld, Jean-Christophe ;
Panzer, Ulf ;
Helmby, Helena ;
Stockinger, Brigitta .
JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (13) :2951-2965
[9]   The many lives of IL-9: a question of survival? [J].
Wilhelm, Christoph ;
Turner, Jan-Eric ;
Van Snick, Jacques ;
Stockinger, Brigitta .
NATURE IMMUNOLOGY, 2012, 13 (07) :637-641
[10]   An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation [J].
Wilhelm, Christoph ;
Hirota, Keiji ;
Stieglitz, Benjamin ;
Van Snick, Jacques ;
Tolaini, Mauro ;
Lahl, Katharina ;
Sparwasser, Tim ;
Helmby, Helena ;
Stockinger, Brigitta .
NATURE IMMUNOLOGY, 2011, 12 (11) :1071-U73
1