Mycoplasma hyopneumoniae bacterins and porcine circovirus type 2 (PCV2) infection: Induction of postweaning multisystemic wasting syndrome (PMWS) in the gnotobiotic swine model of PCV2-associated disease

被引：0
|
作者：
Krakowka, Steven
Ellis, John
McNeilly, Francis
Waldner, Cheryl
Rings, D. Michael
Allan, Gordon
机构：
[1] Ohio State Univ, Goss Lab, Columbus, OH 43210 USA
[2] Ohio State Univ, Coll Vet Med, Dept Vet Biosci, Dept Vet Clin Sci, Columbus, OH 43210 USA
[3] Univ Saskatchewan, Western Coll Vet Med, Dept Vet Microbiol, Dept Large Anim Clin Sci, Saskatoon, SK S7N 0W0, Canada
来源：
CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE | 2007年 / 48卷 / 07期
关键词：
D O I：
暂无
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Groups (5 to 15 per group) of gnotobiotic swine were infected oronasally with porcine circovirus type 2 (PCV2) at 3 days of age and then given 1 of 6 different commercial Mycoplasma hyopneumoniae (M. hyopneumoniae) bacterins as either a single dose (7 d of age, 1 application products) or 2 doses (7 and 21 d of age, 2 application product). Control groups received PCV2 alone (n = 9) or were infected with PCV2 and immunized twice with keyhole limpet hemocyanin (KLH) emulsified in incomplete Freund's adjuvant (ICFA) (n = 7). Five of 7 (71%) PCV2-infected piglets immunized with KLH/ICFA developed mild or overt PMWS, whereas none of 9 piglets infected with PCV2 alone developed PMWS. Five of 12 (42%) piglets vaccinated with a commercial bacterin containing mineral oil adjuvant developed PMWS following vaccination. None of the PCV2-infected piglets in the other bacterin-vaccinated groups developed PMWS in this model of PCV2-associated disease. This difference in prevalence of PMWS in piglets given the mineral oil-adjuvanted M. hyopneumoniae bacterin and the other M. hyopneumoniae bacterin vaccination groups was statistically significant (P < 0.05).
引用
收藏
页码：716 / 724
页数：9
相关论文
共 50 条
  • [41] Porcine circovirus type 2-associated cerebellar vasculitis in postweaning multisystemic wasting syndrome (PMWS)-affected pigs
    Seeliger, F. A.
    Bruegmann, M. L.
    Krueger, L.
    Greiser-Wilke, I.
    Verspohl, J.
    Segales, J.
    Baumgaertner, W.
    VETERINARY PATHOLOGY, 2007, 44 (05) : 621 - 634
  • [42] Prevalence of infection with porcine circovirus-2 (PCV-2) and porcine reproductive and respiratory syndrome virus (PRRSV) in an integrated swine production system experiencing postweaning multisystemic wasting syndrome
    Fraile, Lorenzo
    Calsamiglia, Maria
    Mateu, Enric
    Espinal, Anna
    Cuxart, Anna
    Seminati, Chiara
    Martin, Marga
    Domingo, Mariano
    Segales, Joaquim
    CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, 2009, 73 (04): : 308 - 312
  • [43] Histopathological lesions observed in disease (postweaning multisystemic wasting syndrome) caused by porcine circovirus type 2 (PCV-2) and their diagnostic, pathogenic and clinical evaluation
    Tibor, S
    MAGYAR ALLATORVOSOK LAPJA, 2004, 126 (08) : 465 - 481
  • [44] Effect of porcine circovirus type 2 (PCV2) vaccination on porcine reproductive and respiratory syndrome virus (PRRSV) and PCV2 coinfection
    Opriessnig, T.
    Madson, D. M.
    Prickett, J. R.
    Kuhar, D.
    Lunney, J. K.
    Elsener, J.
    Halbur, P. G.
    VETERINARY MICROBIOLOGY, 2008, 131 (1-2) : 103 - 114
  • [45] A genetically engineered chimeric vaccine against porcine circovirus type 2 (PCV2) improves clinical, pathological and virological outcomes in postweaning multisystemic wasting syndrome affected farms
    Segales, J.
    Urniza, A.
    Alegre, A.
    Bru, T.
    Crisci, E.
    Nofrarias, M.
    Lopez-Soria, S.
    Balasch, M.
    Sibila, M.
    Xu, Z.
    Chu, H. -J.
    Fraile, L.
    Plana-Duran, J.
    VACCINE, 2009, 27 (52) : 7313 - 7321
  • [46] Correlation between the presence of neutralizing antibodies against porcine circovirus 2 (PCV2) and protection against replication of the virus and development of PCV2-associated disease
    Meerts P.
    Misinzo G.
    Lefebvre D.
    Nielsen J.
    Bøtner A.
    Kristensen C.S.
    Nauwynck H.J.
    BMC Veterinary Research, 2 (1)
  • [47] Experimental reproduction of postweaning multisystemic wasting syndrome in pigs by dual infection with Mycoplasma hyopneamoniae and porcine circovirus type 2
    Opriessnig, T
    Thacker, EL
    Yu, S
    Fenaux, M
    Meng, XJ
    Halbur, PG
    VETERINARY PATHOLOGY, 2004, 41 (06) : 624 - 640
  • [48] Porcine reproductive and respiratory syndrome virus (PRRSV) influences infection dynamics of porcine circovirus type 2 (PCV2) subtypes PCV2a and PCV2b by prolonging PCV2 viremia and shedding
    Sinha, A.
    Shen, H. G.
    Schalk, S.
    Beach, N. M.
    Huang, Y. W.
    Meng, X. J.
    Halbur, P. G.
    Opriessnig, T.
    VETERINARY MICROBIOLOGY, 2011, 152 (3-4) : 235 - 246
  • [49] Dynamics of porcine circovirus type 2 infection in a herd of pigs with postweaning multisystemic wasting syndrome
    Rodríguez-Arrioja, GM
    Segalés, J
    Calsamiglia, M
    Resendes, AR
    Balasch, M
    Plana-Durán, J
    Casal, J
    Domingo, M
    AMERICAN JOURNAL OF VETERINARY RESEARCH, 2002, 63 (03) : 354 - 357
  • [50] Genetic and experimental comparison of porcine circovirus type 2 (PCV2) isolates from cases with and without PCV2-associated lesions provides evidence for differences in virulence
    Opriessnig, T.
    McKeown, N. E.
    Zhou, E. -M.
    Meng, X. -J.
    Halbur, P. G.
    JOURNAL OF GENERAL VIROLOGY, 2006, 87 : 2923 - 2932
12345