Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one in zebrafish embryos in vivo model

被引：17

作者：

Cheong, Sun Hee ^{[1
]}

Yang, Hye-Won ^{[2
]}

Ko, Eun-Yi ^{[2
,3
]}

Ahn, Ginnae ^{[1
]}

Lee, WonWoo ^{[2
]}

Kim, Daekyung ^{[3
]}

Jeon, You-Jin ^{[2
]}

Kim, Kil-Nam ^{[3
,4
]}

机构：

[1] Chonnam Natl Univ, Dept Marine Bio Food Sci, Coll Fisheries & Ocean Sci, Yeosu 550749, South Korea

[2] Jeju Natl Univ, Sch Marine Biomed Sci, Jeju 690756, South Korea

[3] KBSI, Jeju Ctr, Jeju 690140, South Korea

[4] Univ Sci & Technol, Dept Marin Biotechnol, Daejeon 305350, South Korea

来源：

FISH & SHELLFISH IMMUNOLOGY | 2016年 / 50卷

关键词：

Trans-1,3-diphenyl-2,3-epoxypropan-1-one (DPEP); Anti-inflammatory; LPS-Treatment; Zebrafish embryos; ANTIOXIDANT ACTIVITIES; CHALCONE DERIVATIVES; INFLAMMATORY MEDIATORS; NITRIC-OXIDE; EXPRESSION; INHIBITION; FLAVONOIDS; ROS;

D O I：

10.1016/j.fsi.2016.01.018

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

In this study, trans-1,3-diphenyl-2,3-epoxypropane-1-one (DPEP) was evaluated for its anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated zebrafish embryos. In the present study, DPEP exhibited potential protective effect in the zebrafish embryos as confirmed by survival rate. DPEP acts as an effective agent against reactive oxygen species (ROS) formation induced by LPS. Moreover, DPEP effectively inhibited LPS-induced nitric oxide (NO) production in zebrafish embryos. In addition, DPEP significantly reduced the expression of inducible NOS (iNOS) and cycloxygenase 2 (COX-2), which generate NO as a key mediator of inflammation in a concentration-dependent manner. According to these results, DPEP could be considered an effective anti-inflammatory agent, which might be further developed as a functional ingredient. This is the first report of the anti-inflammatory activity of DPEP in the LPS-stimulated zebrafish model. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：16 / 20

页数：5

共 25 条

[1] Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood [J].