Preparation of novel hollow mesoporous silica spheres and their sustained-release property

被引：169

作者：

Zhu, YF ^{[1
]}

Shi, JL ^{[1
]}

Shen, WH ^{[1
]}

Chen, HR ^{[1
]}

Dong, XP ^{[1
]}

Ruan, ML ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

NANOTECHNOLOGY | 2005年 / 16卷 / 11期

关键词：

D O I：

10.1088/0957-4484/16/11/027

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Novel hollow mesoporous silica spheres (HMSs) with uniform size and morphology have been successfully synthesized in a facile route using poly(vinylpyrrolidone) (PVP) and cetyltrimethylammonium bromide (CTAB) as co-templates at room temperature. XRD, N-2 adsorption-desorption analysis, FE-SEM, and TEM are used for the characterization of the structure. The hexagonally ordered pore channels are formed on the shell. Ibuprofen (IBU) as a model drug is used to examine the storage capacity and the release behaviour of drug molecules. The storage capacity of hollow mesoporous silica spheres can reach 1133 +/- 52.4 mg g(-1) for ibuprofen, which is three times higher than that of conventional mesoporous materials previously reported (337 mg g(-1)), and the storage capacity is adjustable in a wide range. Furthermore, this system also shows a sustained-release behaviour. The release rates from the IBU-HMSs system (IBU stored in HMSs) increase with the decrease of pH values and the release process follows it Fick's law.

引用

页码：2633 / 2638

页数：6

共 41 条

[21] Photo-switched storage and release of guest molecules in the pore void of coumarin-modified MCM-41 [J].