DNA-Damage-Induced Differentiation in Hematopoietic Stem Cells

被引：22

作者：

Mandal, Pankaj K. ^{[1
]}

Rossi, Derrick J. ^{[1
]}

机构：

[1] Harvard Univ, Program Cellular & Mol Med, Childrens Hosp Boston, Dept Stem Cell & Regenerat Biol,Immune Dis Inst, Boston, MA 02116 USA

来源：

CELL | 2012年 / 148卷 / 05期

关键词：

D O I：

10.1016/j.cell.2012.02.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging of hematopoietic stem cells (HSCs) is accompanied by diminished functional potential. Wang et al. now provide evidence for an HSC-specific differentiation checkpoint mediated by the transcription factor BATF, which limits self-renewal of HSCs in response to the accumulation of DNA damage.

引用

页码：847 / 848

页数：2

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