Structuring hydrophobic domains in Poly(N-isopropylacrylamide-co-Methacrylic acid) hydrogels

被引：5

作者：

Lopez-Gonzalez, Mar ^{[1
]}

Rodrigo, M. Melia ^{[2
]}

Valiente, Mercedes ^{[2
,4
]}

Trabado, Isabel ^{[3
]}

Mendicuti, Francisco ^{[2
,4
]}

Marcelo, Gema ^{[2
,4
]}

机构：

[1] Inst Ciencia & Tecnol Polimeros ICTP CSIC, C Juan de la Cierva 3, Madrid 28006, Spain

[2] Dept Quim Analit Quim Fis & Ingn Quim, Ctra Madrid Barcelona Km 33,600, E-28871 Madrid, Spain

[3] CAI Med Biol, Fac Med & Ciencias Salud, Ctra Madrid Barcelona Km 33600, E-28871 Madrid, Spain

[4] Inst Invest Quim Andres M del Rio, Ctra Madrid Barcelona Km 33,600, E-28871 Madrid, Spain

来源：

EUROPEAN POLYMER JOURNAL | 2020年 / 131卷

关键词：

DRUG-DELIVERY; RELEASE; THERMODYNAMICS; CYCLODEXTRIN; METHYLENE; POLYMERS; PLASMA;

D O I：

10.1016/j.eurpolymj.2020.109695

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels were structured with hydrophobic compartments. To achieve that, N-isopropylacrylamide was copolymerized with methacrylic acid and a small percentage (similar to 0.4 %mol) of (3,4-dihydroxy-5-nitrophenyl)methacrylamide (nitrocatechol monomer) in the presence of sodium dodecyl sulphate at a concentration below its CMC value. All the results support the structuring of poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels with hydrophobic domains in water. These compartments were found to be rich in methacrylic acid and nitrocatechol units. Moreover, the structuring disappeared when hydrogels were swollen at pH 7.4. The structured hydrogel was capable of loading hydrophobic molecules (methyl-2-naphthoate and methyl-9-anthracenecarboxylate) as well as charged drugs (doxorubicin hydrochloride). This hydrogel permitted cell adhesion and growth as well as its detachment when the temperature fell below the LCST.

引用

页数：8

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