An Insight on the Pathogenesis and Treatment of Systemic Lupus Erythematosus

被引：9

作者：

Ali, Murtaza ^{[1
]}

Firoz, Chelapram K. ^{[2
]}

Jabir, Nasimudeen R. ^{[2
]}

Rehan, Mohd ^{[2
]}

Khan, Mohd S. ^{[3
]}

Tabrez, Shams ^{[2
]}

机构：

[1] Jamia Millia Islamia, Dept Biosci, New Delhi, India

[2] King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia

[3] King Saud Univ, Dept Biochem, Coll Sci, Prot Res Chair, Riyadh, Saudi Arabia

来源：

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS | 2018年 / 18卷 / 02期

关键词：

Cytokines; inflammation; interferons; polymorphism; pathogenesis; systemic lupus erythematosus; INTERLEUKIN-10 PROMOTER POLYMORPHISMS; I INTERFERON SYSTEM; RECEPTOR GENE BSMI; NF-KAPPA-B; VITAMIN-D; TYROSINE-PHOSPHATASE; MOLECULAR-BASIS; MYCOPHENOLATE-MOFETIL; SUSCEPTIBILITY GENES; RHEUMATOID-ARTHRITIS;

D O I：

10.2174/1871530318666171207145003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and Objective: Systemic lupus erythematosus (SLE) is a diverse autoimmune disorder, evoked in response to self-immune system that leads to immune complex depositions and organ damage. The exact mechanism of SLE pathogenesis is still unclear but certain genetic and environmental factors have been suggested that could influence its pathogenesis. Discussion: The modulation in B-and T-cell responses and genetic variations could lead to abnormal lymphocyte functions and the production of antibodies against the indigenous proteins and the immune complex depositions. Conclusion: The present review highlights the various causatives of SLE, particularly the genetic alteration in B-and T-cell-related proteins. We have also delineated some of the available therapeutic strategies for the treatment of SLE.

引用

页码：110 / 123

页数：14

共 183 条

[51] Cutting edge: Expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus [J].