Transition metal substituted sandwich-type polyoxometalates with a strong metal-C (imidazole) bond as anticancer agents

被引：57

作者：

Zhao, Hongxia ^{[1
]}

Tao, Li ^{[2
]}

Zhang, Fengmin ^{[3
]}

Zhang, Ying ^{[1
]}

Liu, Yanqing ^{[2
]}

Xu, Hongjie ^{[1
]}

Diao, Guowang ^{[1
]}

Ni, Lubin ^{[1
]}

机构：

[1] Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China

[2] Yangzhou Univ, Coll Med, Yangzhou 225001, Jiangsu, Peoples R China

[3] Yangzhou Univ, Testing Ctr, Yangzhou 225002, Jiangsu, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 08期

基金：

中国国家自然科学基金;

关键词：

IN-VITRO; ANTITUMOR; COMPLEXES; CLUSTERS; ANTIMONY; BINDING; TUMORS; ZN; MN; FE;

D O I：

10.1039/c8cc07884j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two novel sandwich-type polyoxometalates {Na0.7M5.3(H2O)(2)(imi)(2)(Himi)(SbW9O33)(2)}(6-) (M = Ni-II (1), Co-II (2), imi = imidazole) containing a strong M-C-imi bond were synthesized by a tetragonal cluster [Na2Sb8W36O132(H2O)(4)](22-) {Sb8W36} precursor. Compound 1 was highly cytotoxic against gastric cancer cells by arresting the cell cycle in the S-phase and inducing cell apoptosis.

引用

页码：1096 / 1099

页数：4

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