A chitosan hydrogel-based cancer drug delivery system exhibits synergistic antitumor effects by combining with a vaccinia viral vaccine

被引：97

作者：

Han, Hee Dong ^{[1
,2
]}

Song, Chung Kil ^{[1
]}

Park, Yong Sung ^{[2
]}

Noh, Kyung Hee ^{[2
]}

Kim, Jin Hee ^{[2
]}

Hwang, Taewon ^{[1
]}

Kim, Tae Woo ^{[2
,3
]}

Shin, Byung Cheol ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Bioact Mol Delivery & Control Res Team, Taejon 305600, South Korea

[2] Korea Univ, Grad Sch Med, Lab Infect & Immunol, Ansan 425707, Gyeonggi, South Korea

[3] Sookmyung Womens Univ, Res Ctr Womens Dis, Seoul, South Korea

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2008年 / 350卷 / 1-2期

关键词：

hydrogel; doxorubicin; vaccinia vaccine; chemoimmunotherapy;

D O I：

10.1016/j.ijpharm.2007.08.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cancer treatment combining chemotherapy and immunotherapy has been vigorously exploited to further improve cancer therapeutic efficacy. This study investigated a new chemoimmunotherapy approach utilizing hydrogel as a local anti-cancer drug delivery system. Chitosan hydrogel containing doxorubicin (CH-DOX) and vaccinia virus vaccine expressing Sig/E7/LAMP-1 (Vac-Sig/E7/1-AMP-1) were used as chemoimmunotherapeutic agents. It was found that intratumoral injection of CH-DOX effectively inhibited tumor growth itself and, in addition, exhibited a synergistic antitumor effect in combination with a vaccinia virus-based vaccine. This combination did not decrease but rather increased the number of tumor-specific CD8(+)T cells primed by vaccinia virus-mediated vaccination; the resulting antitumor effects were further improved up to 60 days as compared with monotherapy after tumor challenge, and the survival of tumor-bearing mice was dramatically prolonged. This study is a pioneer report that demonstrates the use of a biodegradable hydrogel system as an anti-cancer drug delivery system for successful chemoimmunotherapy. It is hoped that, this study can provide a foundation for a rational approach to improve antitumor efficacy of chemoimmunotherapy. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：27 / 34

页数：8

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