Combined linkage and association sib-pair analysis for quantitative traits

被引：339
作者：
Fulker, DW
Cherny, SS
Sham, PC
Hewitt, JK
机构：
[1] Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA
[2] Univ London, Inst Psychiat, Social Genet & Dev Psychiat Res Ctr, London, England
来源：
AMERICAN JOURNAL OF HUMAN GENETICS | 1999年 / 64卷 / 01期
关键词：
D O I：
10.1086/302193
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
An extension to current maximum-likelihood variance-components procedures for mapping quantitative-trait loci in sib pairs that allows a simultaneous test of allelic association is proposed. The method involves modeling of the allelic means for a test of association, with simultaneous modeling of the sib-pair covariance structure for a test of linkage. By partitioning of the mean effect of a locus into between- and within-sibship components, the method controls for spurious associations due to population stratification and admixture. The power and efficacy of the method are illustrated through simulation of various models of both real and spurious association.
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收藏
页码：259 / 267
页数：9
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