The involvement of p38 MAPK in transforming growth factor β1-induced apoptosis in murine hepatocytes

被引：53

作者：

Liao, JH ^{[1
]}

Chen, JS ^{[1
]}

Chai, MQ ^{[1
]}

Zhao, S ^{[1
]}

Song, JG ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China

来源：

CELL RESEARCH | 2001年 / 11卷 / 02期

关键词：

transforming growth factor beta; apoptosis; p38; hepatocyte; signal transduction;

D O I：

10.1038/sj.cr.7290072

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We reported in this manuscript that TGF-beta1 induces apoptosis in AML12 murine hepatocytes, which is associated with the activation of p38 MAPK signaling pathway. SB202190, a specific inhibitor of p38 MAPK, strongly inhibited the TGF-beta1-induced apoptosis and PAI-1 promoter activity. Treatment of cells with TGF-beta1 activates p38. Furthermore, over-expression of dominant negative mutant p38 also reduced the TGF-beta1-induced apoptosis. The data indicate that the activation of p38 is involved in TGF-beta1-mediated gene expression and apoptosis.

引用

页码：89 / 94

页数：6

共 36 条

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