New Paracoccidioides brasiliensis isolate reveals unexpected genomic variability in this human pathogen

被引：85

作者：

Carrero, Lilia L. ^{[1
]}

Nino-Vega, Gustavo ^{[1
]}

Teixeira, Marcus M. ^{[2
]}

Carvalho, Maria Jose A. ^{[2
]}

Soares, Celia M. A. ^{[3
]}

Pereira, Maristela ^{[3
]}

Jesuino, Rosalia S. A. ^{[3
]}

McEwen, Juan G. ^{[4
,5
]}

Mendoza, Leonel ^{[6
]}

Taylor, John W. ^{[7
]}

Felipe, Maria Sueli ^{[2
]}

San-Blas, Gioconda ^{[1
]}

机构：

[1] Inst Venezolano Invest Cient, Lab Micol, Caracas 21827, Venezuela

[2] Univ Brasilia, BR-70910900 Brasilia, DF, Brazil

[3] Univ Fed Goias, Goias, Brazil

[4] Univ Antioquia, Corp Invest Biol, Medellin, Colombia

[5] Univ Antioquia, Fac Med, Medellin, Colombia

[6] Michigan State Univ, Med Technol Program, E Lansing, MI 48824 USA

[7] Univ Calif Berkeley, Berkeley, CA 94720 USA

来源：

FUNGAL GENETICS AND BIOLOGY | 2008年 / 45卷 / 05期

关键词：

Paracoccidioides brasiliensis; molecular phylogeny; molecular variability; genealogical concordance;

D O I：

10.1016/j.fgb.2008.02.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

By means of genealogical concordance phylogenetic species recognition (GCPSR), we have investigated coding and non-coding regions from various genes and the ITS sequences of 7 new and 14 known isolates of Paracoccidioides brasiliensis. Such isolates grouped within the three phylogenetic groups recently reported in the genus Paracoccidioides, with one single exception, i.e., Pb01, a strain that has been the subject of intense molecular studies for many years. This isolate clearly separates from all other Paracoccidioides isolates in phylogenetic analyses and greatly increases the genomic variation known in this genus. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：605 / 612

页数：8

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