Cytotoxicity of zinc oxide nanoparticles coupled with folic acid and polyethylene glycol

被引：0
作者：
Khalid, A. D. [1 ]
N-ur-Rehman [2 ]
Hadi, F. [3 ]
Iqbal, S. S. [1 ]
Buzdar, S. A. [2 ]
Khan, A. K. [2 ]
机构：
[1] Univ Lahore, Dept Phys, Lahore, Pakistan
[2] Islamia Univ Bahawalpur, Inst Phys, Bahawalpur 63100, Pakistan
[3] Univ Lahore, Inst Mol Biol & Biotechnol, Lahore, Pakistan
来源：
DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES | 2022年 / 17卷 / 01期
关键词：
Zinc oxide; MTT assay; Folic acid; Poly ethylene glycol; ZNO NANOPARTICLES; ANTIBACTERIAL ACTIVITY; METAL; SIZE;
D O I：
暂无
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The anticancer mediators claim their activity in liquid form as a biocompatible and use in bios stems, which are mostly collected in fluid form. Control on the stability of metal oxide nanoparticles in parallel reducing the effect of large amount on their biological and cytotoxicity activities, remains a challenge. Here anticancer activity and cytotoxicity zinc oxide nanoparticles (NPs) have been presented that are coated with folic acid (F.A) and polyethylene glycol (PEG). The nanoparticles were synthesized by wet chemical method and characterized by x-ray diffraction; scanning electron microscopy and Fourier transform infrared spectroscopy. The cytotoxicity studies were performed on HepG2 cells.MMT assay was used to check the cell viability. The PEG and F.A capped ZnO NPs have shown reduction in cytotoxicity as compare to bare ZnO nanoparticles.
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收藏
页码：73 / 79
页数：7
相关论文
共 31 条
[1]   Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells [J].
Ahamed, Maqusood ;
Akhtar, Mohd Javed ;
Siddiqui, Maqsood A. ;
Ahmad, Javed ;
Musarrat, Javed ;
Al-Khedhairy, Abdulaziz A. ;
AlSalhi, Mohamad S. ;
Alrokayan, Salman A. .
TOXICOLOGY, 2011, 283 (2-3) :101-108
[2]   Role of capping agents in controlling silver nanoparticles size, antibacterial activity and potential application as optical hydrogen peroxide sensor [J].
Ajitha, B. ;
Reddy, Y. Ashok Kumar ;
Reddy, P. Sreedhara ;
Jeon, Hwan-Jin ;
Ahn, Chi Won .
RSC ADVANCES, 2016, 6 (42) :36171-36179
[3]   Nanoalumina induces apoptosis by impairing antioxidant enzyme systems in human hepatocarcinoma cells [J].
Alarifi, Saud ;
Ali, Daoud ;
Alkahtani, Saad .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2015, 10 :3751-3760
[4]  
Andreescu S., 2012, FINE PARTICLES MED P, P57, DOI DOI 10.1007/978-1-4614-0379-1_3
[5]   Reduction of pulmonary toxicity of metal oxide nanoparticles by phosphonate-based surface passivation [J].
Cai, Xiaoming ;
Lee, Anson ;
Ji, Zhaoxia ;
Huang, Cynthia ;
Chang, Chong Hyun ;
Wang, Xiang ;
Liao, Yu-Pei ;
Xia, Tian ;
Li, Ruibin .
PARTICLE AND FIBRE TOXICOLOGY, 2017, 14
[6]   Differential cytotoxicity of metal oxide nanoparticles [J].
Chen, Jian ;
Zhu, Jinmin ;
Cho, Hyun-Hee ;
Cui, Kemi ;
Li, Fuhai ;
Zhou, Xiaobo ;
Rogers, Jack T. ;
Wong, Stephen T. C. ;
Huang, Xudong .
JOURNAL OF EXPERIMENTAL NANOSCIENCE, 2008, 3 (04) :321-328
[7]   Size-dependent cytotoxicity study of ZnO nanoparticles in HepG2 cells [J].
Chen, Pengyu ;
Wang, Han ;
He, Man ;
Chen, Beibei ;
Yang, Bin ;
Hu, Bin .
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 171 :337-346
[8]   Novel synthesis and structural analysis of zinc oxide nanoparticles for the non enzymatic glucose biosensor [J].
Dayakar, T. ;
Rao, Venkateswara K. ;
Bikshalu, K. ;
Rajendar, V ;
Park, Si-Hyun .
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 75 :1472-1479
[9]   Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model [J].
Elje, Elisabeth ;
Mariussen, Espen ;
Moriones, Oscar H. ;
Bastus, Neus G. ;
Puntes, Victor ;
Kohl, Yvonne ;
Dusinska, Maria ;
Runden-Pran, Elise .
NANOMATERIALS, 2020, 10 (03)
[10]   Hazard assessment of polymer-capped CuO and ZnO nanocolloids: A contribution to the safe-by-design implementation of biocidal agents [J].
Fiandra, Luisa ;
Bonfanti, Patrizia ;
Piunno, Ylenia ;
Nagvenkar, Anjani P. ;
Perlesthein, Ilana ;
Gedanken, Aharon ;
Saibene, Melissa ;
Colombo, Anita ;
Mantecca, Paride .
NANOIMPACT, 2020, 17
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