Small-Molecule CSF1R Inhibitors as Anticancer Agents

被引：34

作者：

Xun, Qiuju ^{[1
]}

Wang, Zhen ^{[1
]}

Hu, Xianglong ^{[1
]}

Ding, Ke ^{[1
]}

Lu, Xiaoyun ^{[1
]}

机构：

[1] Jinan Univ, Sch Pharm, Int Cooperat Lab Tradit Chinese Med Modernizat &, Chinese Minist Educ MOE, 601 Huangpu Ave West, Guangzhou 510632, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2020年 / 27卷 / 23期

基金：

中国国家自然科学基金;

关键词：

Tumor-Associated Macrophages (TAMs); CSF1R; inhibitors; anticancer agents; pharmacophore features; clinical trials; COLONY-STIMULATING FACTOR; TUMOR-ASSOCIATED MACROPHAGES; FMS TYROSINE KINASE; RECEPTOR C-FMS; FACTOR-I; POTENT CLASS; MONOCLONAL-ANTIBODY; CSF-1R INHIBITOR; GROWTH-FACTORS; LUNG-CANCER;

D O I：

10.2174/1573394715666190618121649

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Persuasive evidence has been presented linking the infiltration of Tumor-Associated Macrophages (TAMs) with the driving force of tumorigenesis and in the suppression of antitumor immunity. In this context CSF1R, the cellular receptor for Colony Stimulating Factor-1 (CSF1) and Interleukin 34 (IL-34), occupies a central role in manipulating the behavior of TAMs and the dysregulation of CSF1R signaling has been implicated in cancer progression and immunosuppression in many specific cancers. Consequently, CSF1R kinase has been a target of great interest in cancer treatment and significant research efforts have focused on the development of small-molecule CSF1R inhibitors. In this review, we highlight current progress on the development of these small molecule CSF1R inhibitors as anticancer agents. Special attention is paid to the compounds available in advanced clinical trials.

引用

收藏

页码：3944 / 3966

页数：23

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