Bile Composition as a Diagnostic and Prognostic Tool in Liver Transplantation

被引：36
作者：
Bruggenwirth, Isabel M. A. [1 ,2 ]
Porte, Robert J. [2 ]
Martins, Paulo N. [1 ]
机构：
[1] Univ Massachusetts, Div Organ Transplantat, Dept Surg, UMass Mem Med Ctr, 55 North Lake Ave, Worcester, MA 01655 USA
[2] Univ Med Ctr Groningen, Dept Surg, Sect Hepatobiliary Surg & Liver Transplantat, Groningen, Netherlands
来源：
LIVER TRANSPLANTATION | 2020年 / 26卷 / 09期
关键词：
NORMOTHERMIC MACHINE PERFUSION; ACUTE CELLULAR REJECTION; DUCT INJURY; BILIARY STRICTURES; LIPID-COMPOSITION; SALT TOXICITY; DONOR LIVERS; PRESERVATION; SECRETION; COMPLICATIONS;
D O I：
10.1002/lt.25771
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Bile secretion and composition reflects the functional status of hepatocytes and cholangiocytes. Bile composition can have a role in the assessment of donor grafts before implantation in the recipient. In addition, changes in bile composition after liver transplantation can serve as a diagnostic and prognostic tool to predict posttransplant complications, such as primary nonfunction, acute cellular rejection, or nonanastomotic biliary strictures. With the popularization of liver machine perfusion preservation in the clinical setting, there is a revisited interest in biliary biomarkers to assess graft viability before implantation. This review discusses current literature on biliary biomarkers that could predict or assess liver graft and bile duct viability. Bile composition offers an exciting and novel perspective in the search for reliable hepatocyte and cholangiocyte viability biomarkers.
引用
收藏
页码：1177 / 1187
页数：11
相关论文
共 63 条
[1]   DETECTION OF CIRCULATING INTERCELLULAR-ADHESION MOLECULE-1 AFTER LIVER-TRANSPLANTATION - EVIDENCE OF LOCAL RELEASE WITHIN THE LIVER DURING GRAFT-REJECTION [J].
ADAMS, DH ;
MAINOLFI, E ;
ELIAS, E ;
NEUBERGER, JM ;
ROTHLEIN, R .
TRANSPLANTATION, 1993, 55 (01) :83-87
[2]  
ADAMS DH, 1989, LANCET, V1, P469
[3]  
Baumgartner U, 1995, HEPATO-GASTROENTEROL, V42, P950
[4]   Identification and Validation of the Predictive Capacity of Risk Factors and Models in Liver Transplantation Over Time [J].
Blok, Joris J. ;
Putter, Hein ;
Metselaar, Herold J. ;
Porte, Robert J. ;
Gonella, Federica ;
de Jonge, Jeroen ;
van den Berg, Aad P. ;
van der Zande, Josephine ;
de Boer, Jacob D. ;
van Hoek, Bart ;
Braat, Andries E. .
TRANSPLANTATION DIRECT, 2018, 4 (09)
[5]   Normothermic Acellular Ex Vivo Liver Perfusion Reduces Liver and Bile Duct Injury of Pig Livers Retrieved After Cardiac Death [J].
Boehnert, M. U. ;
Yeung, J. C. ;
Bazerbachi, F. ;
Knaak, J. M. ;
Selzner, N. ;
McGilvray, I. D. ;
Rotstein, O. D. ;
Adeyi, O. A. ;
Kandel, S. M. ;
Rogalla, P. ;
Yip, P. M. ;
Levy, G. A. ;
Keshavjee, S. ;
Grant, D. R. ;
Selzner, M. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2013, 13 (06) :1441-1449
[6]  
Boteon YL, 2019, AM J TRANSPLANT, V19, P760
[7]  
Boteon YL, 2019, AM J TRANSPLANT S3, V19
[8]   Bile Formation and Secretion [J].
Boyer, James L. .
COMPREHENSIVE PHYSIOLOGY, 2013, 3 (03) :1035-1078
[9]   MECHANICS OF BILE SECRETION - EFFECT OF PERFUSION PRESSURE AND TEMPERATURE ON BILE FLOW AND BILE SECRETION PRESSURE [J].
BRAUER, RW ;
LEONG, GF ;
HOLLOWAY, RJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1954, 177 (01) :103-112
[10]   Normothermic Perfusion A New Paradigm for Organ Preservation [J].
Brockmann, Jens ;
Reddy, Srikanth ;
Coussios, Constantin ;
Pigott, David ;
Guirriero, Dino ;
Hughes, David ;
Morovat, Alireza ;
Roy, Debabrata ;
Winter, Lucy ;
Friend, Peter J. .
ANNALS OF SURGERY, 2009, 250 (01) :1-6
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