Small cell lung cancer in never-smokers

被引：27

作者：

Torres-Duran, Maria ^{[1
]}

Ruano-Ravina, Alberto ^{[2
,3
,4
]}

Kelsey, Karl T. ^{[4
]}

Parente-Lamelas, Isaura ^{[5
]}

Provencio, Mariano ^{[6
]}

Leiro-Fernandez, Virginia ^{[1
]}

Abal-Arca, Jose ^{[5
]}

Montero-Martinez, Carmen ^{[7
]}

Vidal-Garcia, Iria ^{[7
]}

Pena, Carolina ^{[8
]}

Castro-Anon, Olalla ^{[9
]}

Golpe-Gomez, Antonio ^{[10
]}

Martinez, Cristina ^{[11
]}

Guzman-Taveras, Rosirys ^{[11
]}

Jose Mejuto-Marti, Mara ^{[12
]}

Fernandez-Villar, Alberto ^{[1
]}

Miguel Barros-Dios, Juan ^{[2
,3
,13
]}

机构：

[1] Univ Hosp Complex Vigo, Serv Pneumol, Vigo, Spain

[2] Univ Santiago de Compostela, Dept Prevent Med & Publ Hlth, Santiago De Compostela, Spain

[3] CIBERESP, Barcelona, Spain

[4] Brown Univ, Dept Epidemiol, Brown Sch Publ Hlth, Providence, RI 02912 USA

[5] Ourense Hosp Complex, Serv Pneumol, Orense, Spain

[6] Puerta Hierro Univ Hosp, Serv Oncol, Madrid, Spain

[7] Univ Hosp Complex A Coruna, Serv Pneumol, La Coruna, Spain

[8] Oncol Ctr A Coruna, Serv Oncol, La Coruna, Spain

[9] Hosp Lucus Augusti, Serv Pneumol, Lugo, Spain

[10] Santiago de Compostela Univ Clin Hosp, Serv Pneumol, Santiago De Compostela, Spain

[11] Univ Hosp Asturias, Natl Inst Silicosis, Oviedo, Spain

[12] Arquitecto Marcide Hosp, Serv Pneumol, Ferrol, Spain

[13] Univ Hosp Complex Santiago de Compostela, Serv Prevent Med, Santiago De Compostela, Spain

来源：

EUROPEAN RESPIRATORY JOURNAL | 2016年 / 47卷 / 03期

关键词：

PROGNOSTIC-FACTORS; RESIDENTIAL RADON; TOBACCO-SMOKE; EXPOSURE; SURVIVAL; INDEX; RISK;

D O I：

10.1183/13993003.01524-2015

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Our aim was to describe the characteristics of a case-series of never-smoker small cell lung cancer (SCLC) cases. Cases of SCLC were selected from a prospective, multicenter, hospital-based case-control study performed in Spain. Participants were never-smokers older than 30 years with an anatomo-pathological confirmation of primary lung cancer. We collected clinical and epidemiological variables according to the study's protocol. We included 19 SCLC cases, 18 females (94.7%), median age 75 years (interquartile range (IQR) 70-80 years). Median residential radon concentration was 195 Bq.m(-3) (IQR 130-229 Bq.m(-3)). 10 patients had limited disease and nine had extended disease. Median survival was 242 days (IQR 94-496 days); 1- and 2-year survival were 36.8% and 17.6%, respectively. Survival was much higher for individuals with limited disease than for those with extended disease (median 336 versus 235 days; 1-year survival 50% versus 22.2% and 2-year survival 27% versus 0%, respectively). Performance status at diagnosis was closely related to survival. SCLC is an infrequent, highly aggressive disease in never-smokers. Survival is poor, even for limited disease. Age at diagnosis in SCLC is higher than that observed for never-smokers with adenocarcinoma. Residential radon exposure is higher than the action levels recommended by the World Health Organization.

引用

页码：947 / 953

页数：7

共 31 条

[1]

[Anonymous], 2018, ANTI-CANCER DRUG, DOI [DOI 10.3322/caac.20115, DOI 10.1097/CAD.0000000000000617]

[2] PROGNOSTIC FACTORS IN LUNG-CANCER - TABLES AND COMMENTS [J].

BUCCHERI, G ;

FERRIGNO, D .

EUROPEAN RESPIRATORY JOURNAL, 1994, 7 (07) :1350-1364

[3]

Darby S, 2005, BMJ-BRIT MED J, V16, P137

[4] International lung cancer trends by histologic type:: male:female differences diminishing and adenocarcinoma rates rising [J].

Devesa, SS ;

Bray, F ;

Vizcaino, AP ;

Parkin, DM .

INTERNATIONAL JOURNAL OF CANCER, 2005, 117 (02) :294-299

[5] Tumor Response and Progression-Free Survival as Potential Surrogate Endpoints for Overall Survival in Extensive Stage Small-Cell Lung Cancer Findings on the Basis of North Central Cancer Treatment Group Trials [J].

Foster, Nathan R. ;

Qi, Yingwei ;

Shi, Qian ;

Krook, James E. ;

Kugler, John W. ;

Jett, James R. ;

Molina, Julian R. ;

Schild, Steven E. ;

Adjei, Alex A. ;

Mandrekar, Sumithra J. .

CANCER, 2011, 117 (06) :1262-1271

[6] Small-cell lung cancer (SCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up [J].

Frueh, M. ;

De Ruysscher, D. ;

Popat, S. ;

Crino, L. ;

Peters, S. ;

Felip, E. .

ANNALS OF ONCOLOGY, 2013, 24 :99-105

[7] Guidelines for biomarker testing in advanced non-small-cell lung cancer. A national consensus of the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP) [J].

Garrido, Pilar ;

de Castro, Javier ;

Concha, Angel ;

Felip, Enriqueta ;

Isla, Dolores ;

Lopez-Rios, Fernando ;

Paz-Ares, Luis ;

Ramirez, Jose ;

Sanz, Julian ;

Javier Gomez, Jose .

CLINICAL & TRANSLATIONAL ONCOLOGY, 2012, 14 (05) :338-349

[8] Intercomparison exercise on external gamma dose rate under field conditions at the laboratory of natural radiation (Saelices el Chico, Spain) [J].

Gutierrez-Villanueva, J. L. ;

Sainz-Fernandez, C. ;

Fuente-Merino, I. ;

Saez-Vergara, J. C. ;

Correa-Garces, E. ;

Quindos-Poncela, L. S. .

RADIATION PROTECTION DOSIMETRY, 2013, 155 (04) :459-466

[9] Molecular origins of cancer: Lung cancer [J].

Herbst, Roy S. ;

Heymach, John V. ;

Lippman, Scott M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (13) :1367-1380

[10] The changing cigarette, 1950-1995 [J].

Hoffmann, D ;

Hoffmann, I .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, 1997, 50 (04) :307-364

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